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Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma

BACKGROUND: The role of TMEM176A in human hepatocellular carcinoma (HCC) is unknown. This study explored the epigenetic regulation and function of TMEM176A in human HCC. MATERIALS AND METHODS: Twelve HCC cell lines and 126 cases of primary cancer were analyzed. Methylation-specific PCR, immunohistoc...

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Detalles Bibliográficos
Autores principales:	Li, Hongxia, Zhang, Meiying, Linghu, Enqiang, Zhou, Fuyou, Herman, James G., Hu, Liming, Guo, Mingzhou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219251/ https://www.ncbi.nlm.nih.gov/pubmed/30400968 http://dx.doi.org/10.1186/s13148-018-0570-4

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