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An assessment of variation in macular volume and RNFL thickness in myopes using OCT and their significance for early diagnosis of primary open-angle glaucoma
PURPOSE: An assessment of variation in Macular Volume and RNFL Thickness in myopes using OCT, and their significance for early diagnosis of Primary Open Angle Glaucoma(POAG). MATERIALS AND METHOD: Total of 122 eyes of 61 Indian Myopic subjects of both sex and various age groups underwent retinal ner...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219317/ https://www.ncbi.nlm.nih.gov/pubmed/30505115 http://dx.doi.org/10.4103/ojo.OJO_92_2017 |
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author | Chaturvedi, Pravda Chauhan, Arvind Singh, Punit Kumar |
author_facet | Chaturvedi, Pravda Chauhan, Arvind Singh, Punit Kumar |
author_sort | Chaturvedi, Pravda |
collection | PubMed |
description | PURPOSE: An assessment of variation in Macular Volume and RNFL Thickness in myopes using OCT, and their significance for early diagnosis of Primary Open Angle Glaucoma(POAG). MATERIALS AND METHOD: Total of 122 eyes of 61 Indian Myopic subjects of both sex and various age groups underwent retinal nerve fiber layer thickness, macular volume in 6mm analysis by Rtvue Avanti SD-OCT, Optovue Technology V6.1.1,after taking due consent from ethical committee. Subjects were divided into two groups based on their refractive error, Group A <6 D and Group B >6D. The results were evaluated to determine the above mentioned measurements and their variation with myopic refractive error. RESULTS: The RNFL thickness in four Quadrants and an inner circle were taken. The mean thickness in inner circle in both groups were 101.48μm (SD±13.34 μm) and 92.38 μm (SD±11.99μm) respectively, which was statistically significant. The difference was also significant in superior, nasal and inferior quadrant. Statistically the difference was not significant in temporal quadrant. The macular volume was calculated in 6mm diameter. The mean value in Group A was 7.82mm(3)±0.54 mm (3). The mean value in Group B was 7.44mm(3)±0.98mm(3). The statistical analysis showed the difference between the two groups is statistically significant. CONCLUSION: RNFL thickness is an established way to diagnose open angle glaucoma in preperimetric stage. Macular Volume is also found to be co-related with the risk. Myopes are known to be at higher risk to develop POAG. Hence, measurement of RNFL thickness by OCT should be made a mandatory investigation in High Myopes. |
format | Online Article Text |
id | pubmed-6219317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-62193172018-11-30 An assessment of variation in macular volume and RNFL thickness in myopes using OCT and their significance for early diagnosis of primary open-angle glaucoma Chaturvedi, Pravda Chauhan, Arvind Singh, Punit Kumar Oman J Ophthalmol Original Article PURPOSE: An assessment of variation in Macular Volume and RNFL Thickness in myopes using OCT, and their significance for early diagnosis of Primary Open Angle Glaucoma(POAG). MATERIALS AND METHOD: Total of 122 eyes of 61 Indian Myopic subjects of both sex and various age groups underwent retinal nerve fiber layer thickness, macular volume in 6mm analysis by Rtvue Avanti SD-OCT, Optovue Technology V6.1.1,after taking due consent from ethical committee. Subjects were divided into two groups based on their refractive error, Group A <6 D and Group B >6D. The results were evaluated to determine the above mentioned measurements and their variation with myopic refractive error. RESULTS: The RNFL thickness in four Quadrants and an inner circle were taken. The mean thickness in inner circle in both groups were 101.48μm (SD±13.34 μm) and 92.38 μm (SD±11.99μm) respectively, which was statistically significant. The difference was also significant in superior, nasal and inferior quadrant. Statistically the difference was not significant in temporal quadrant. The macular volume was calculated in 6mm diameter. The mean value in Group A was 7.82mm(3)±0.54 mm (3). The mean value in Group B was 7.44mm(3)±0.98mm(3). The statistical analysis showed the difference between the two groups is statistically significant. CONCLUSION: RNFL thickness is an established way to diagnose open angle glaucoma in preperimetric stage. Macular Volume is also found to be co-related with the risk. Myopes are known to be at higher risk to develop POAG. Hence, measurement of RNFL thickness by OCT should be made a mandatory investigation in High Myopes. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6219317/ /pubmed/30505115 http://dx.doi.org/10.4103/ojo.OJO_92_2017 Text en Copyright: © 2018 Oman Ophthalmic Society http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Chaturvedi, Pravda Chauhan, Arvind Singh, Punit Kumar An assessment of variation in macular volume and RNFL thickness in myopes using OCT and their significance for early diagnosis of primary open-angle glaucoma |
title | An assessment of variation in macular volume and RNFL thickness in myopes using OCT and their significance for early diagnosis of primary open-angle glaucoma |
title_full | An assessment of variation in macular volume and RNFL thickness in myopes using OCT and their significance for early diagnosis of primary open-angle glaucoma |
title_fullStr | An assessment of variation in macular volume and RNFL thickness in myopes using OCT and their significance for early diagnosis of primary open-angle glaucoma |
title_full_unstemmed | An assessment of variation in macular volume and RNFL thickness in myopes using OCT and their significance for early diagnosis of primary open-angle glaucoma |
title_short | An assessment of variation in macular volume and RNFL thickness in myopes using OCT and their significance for early diagnosis of primary open-angle glaucoma |
title_sort | assessment of variation in macular volume and rnfl thickness in myopes using oct and their significance for early diagnosis of primary open-angle glaucoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219317/ https://www.ncbi.nlm.nih.gov/pubmed/30505115 http://dx.doi.org/10.4103/ojo.OJO_92_2017 |
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