The effects of cytochrome P450 2C19 polymorphism on the metabolism of voriconazole in vitro

BACKGROUND: CYP/CYP450 2C19 (CYP2C19) is a highly polymorphic enzyme and exhibits individual differences in metabolic activity. The purpose of this research was mainly to explore the catalytic activities of 30 CYP2C19 variants on the substrate voriconazole in vitro, including 24 novel CYP2C19 varian...

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Detalles Bibliográficos
Autores principales: Xu, Ren-ai, Gu, Er-min, Liu, Teng-hui, Ou-yang, Qiu-geng, Hu, Guo-xin, Cai, Jian-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219421/
https://www.ncbi.nlm.nih.gov/pubmed/30464555
http://dx.doi.org/10.2147/IDR.S179078

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