An observational study of Chinese adults with relapsed/refractory Philadelphia-negative acute lymphoblastic leukemia

AIM: Chinese adults with relapsed/refractory Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia (Ph- ALL) have poor outcomes. PATIENTS & METHODS: We conducted a nationwide, retrospective, observational study to assess outcomes in this patient population. RESULTS: Of t...

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Detalles Bibliográficos
Autores principales: Ma, Jun, Liu, Ting, Jin, Jie, Hu, Jianda, Liu, Qifa, Wang, Jianxiang, Shen, Zhixiang, Du, Xin, Jiang, Bin, Meng, Xianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219430/
https://www.ncbi.nlm.nih.gov/pubmed/30405901
http://dx.doi.org/10.2217/ijh-2018-0006
Descripción
Sumario:AIM: Chinese adults with relapsed/refractory Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia (Ph- ALL) have poor outcomes. PATIENTS & METHODS: We conducted a nationwide, retrospective, observational study to assess outcomes in this patient population. RESULTS: Of the 270 enrolled patients, 31% of patients at last salvage achieved complete remission (CR) or CR with partial hematologic recovery (CRh), with median time to CR/CRh of 30 days and median CR/CRh duration of 2.7 months. The CR/CRh rate was more favorable with earlier versus later lines of salvage (41, 24 and 17% at first, second and third or later salvages, respectively). CONCLUSION: This dataset serves as an important reference of real-world outcomes using currently available chemotherapy regimens for high-risk Chinese adults with relapsed/refractory Ph- ALL.

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