Sickle Cell Disease Clinical Trials and Phenotypes

Sickle cell disease, one of the world’s most common genetic disorders is prevalent in sub-Saharan Africa. The trans-Atlantic slave trade accounted for the gene movement from Africa to the Caribbean and United States of America and lately, migration has resulted in the introduction of the gene to the...

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Detalles Bibliográficos
Autores principales: Ezekekwu, Chinedu A, Kotila, Taiwo R, Akingbola, Titilola S, Lettre, Guillaume, Gordeuk, Victor R, Cooper, Richard S, DeBaun, Michael R, Inusa, Baba, Tayo, Bamidele O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219473/
https://www.ncbi.nlm.nih.gov/pubmed/30410998
http://dx.doi.org/10.4172/2329-891X.1000259
Descripción
Sumario:Sickle cell disease, one of the world’s most common genetic disorders is prevalent in sub-Saharan Africa. The trans-Atlantic slave trade accounted for the gene movement from Africa to the Caribbean and United States of America and lately, migration has resulted in the introduction of the gene to the United Kingdom and other parts of Europe. Different haplotypes exist, however the differences in these haplotypes are not sufficient to explain the different clinical variations within the same region or different settings.

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