Knock-in of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice

Wilms tumor 1 (WT1) is a zinc finger transcriptional regulator, and has been implicated as both a tumor suppressor and oncogene in various malignancies. Mutations in the DNA-binding domain of the WT1 gene are described in 10–15% of normal-karyotype AML (NK-AML) in pediatric and adult patients. Simil...

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Detalles Bibliográficos
Autores principales: Annesley, Colleen E., Rabik, Cara, Duffield, Amy S., Rau, Rachel E., Magoon, Daniel, Li, Li, Huff, Vicki, Small, Donald, Loeb, David M., Brown, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219680/
https://www.ncbi.nlm.nih.gov/pubmed/30450160
http://dx.doi.org/10.18632/oncotarget.26238

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