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Ring nucleases deactivate Type III CRISPR ribonucleases by degrading cyclic oligoadenylate

The CRISPR system provides adaptive immunity against mobile genetic elements in prokaryotes, utilising small CRISPR RNAs which direct effector complexes to degrade invading nucleic acids1–3. Type III effector complexes were recently demonstrated to synthesise a novel second messenger, cyclic oligoad...

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Detalles Bibliográficos
Autores principales:	Athukoralage, Januka S, Rouillon, Christophe, Graham, Shirley, Grüschow, Sabine, White, Malcolm F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219705/ https://www.ncbi.nlm.nih.gov/pubmed/30232454 http://dx.doi.org/10.1038/s41586-018-0557-5

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