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Xrp1 genetically interacts with the ALS-associated FUS orthologue caz and mediates its toxicity

Cabeza (caz) is the single Drosophila melanogaster orthologue of the human FET proteins FUS, TAF15, and EWSR1, which have been implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. In this study, we identified Xrp1, a nuclear chromatin-binding protein, as a key modifier of c...

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Detalles Bibliográficos
Autores principales:	Mallik, Moushami, Catinozzi, Marica, Hug, Clemens B., Zhang, Li, Wagner, Marina, Bussmann, Julia, Bittern, Jonas, Mersmann, Sina, Klämbt, Christian, Drexler, Hannes C.A., Huynen, Martijn A., Vaquerizas, Juan M., Storkebaum, Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219715/ https://www.ncbi.nlm.nih.gov/pubmed/30209068 http://dx.doi.org/10.1083/jcb.201802151

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