Nuclear rupture at sites of high curvature compromises retention of DNA repair factors

The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix—all of which sustain forces, but their relationships to DNA damage are obscure. We show that nuclear rupture with cytoplasmic mislocalization of multiple DNA repair factors correlates with high nuclear curvatur...

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Detalles Bibliográficos
Autores principales: Xia, Yuntao, Ivanovska, Irena L., Zhu, Kuangzheng, Smith, Lucas, Irianto, Jerome, Pfeifer, Charlotte R., Alvey, Cory M., Ji, Jiazheng, Liu, Dazhen, Cho, Sangkyun, Bennett, Rachel R., Liu, Andrea J., Greenberg, Roger A., Discher, Dennis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219729/
https://www.ncbi.nlm.nih.gov/pubmed/30171044
http://dx.doi.org/10.1083/jcb.201711161

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