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USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein

Th2 immune response is critical for allergic asthma pathogenesis. Molecular mechanisms for regulating Th2 immunity are still not well understood. Here we report that the ubiquitin-specific protease USP38 is crucial for Th2-mediated allergic asthma. TCR stimulation up-regulated the USP38 level, and U...

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Detalles Bibliográficos
Autores principales:	Chen, Siyuan, Yun, Fenglin, Yao, Yikun, Cao, Mengtao, Zhang, Yifan, Wang, Jingjing, Song, Xinyang, Qian, Youcun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219735/ https://www.ncbi.nlm.nih.gov/pubmed/30224386 http://dx.doi.org/10.1084/jem.20172026

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