Targeting neuro–immune communication in neurodegeneration: Challenges and opportunities

Immune cells patrol the brain and can support its function, but can we modulate brain–immune communication to fight neurological diseases? Here, we briefly discuss the mechanisms orchestrating the cross-talk between the brain and the immune system and describe how targeting this interaction in a wel...

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Detalles Bibliográficos
Autores principales: Deczkowska, Aleksandra, Schwartz, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219738/
https://www.ncbi.nlm.nih.gov/pubmed/30301785
http://dx.doi.org/10.1084/jem.20181737
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author Deczkowska, Aleksandra
Schwartz, Michal
author_facet Deczkowska, Aleksandra
Schwartz, Michal
author_sort Deczkowska, Aleksandra
collection PubMed
description Immune cells patrol the brain and can support its function, but can we modulate brain–immune communication to fight neurological diseases? Here, we briefly discuss the mechanisms orchestrating the cross-talk between the brain and the immune system and describe how targeting this interaction in a well-controlled manner could be developed as a universal therapeutic approach to treat neurodegeneration.
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spelling pubmed-62197382019-05-05 Targeting neuro–immune communication in neurodegeneration: Challenges and opportunities Deczkowska, Aleksandra Schwartz, Michal J Exp Med Viewpoint Immune cells patrol the brain and can support its function, but can we modulate brain–immune communication to fight neurological diseases? Here, we briefly discuss the mechanisms orchestrating the cross-talk between the brain and the immune system and describe how targeting this interaction in a well-controlled manner could be developed as a universal therapeutic approach to treat neurodegeneration. Rockefeller University Press 2018-11-05 /pmc/articles/PMC6219738/ /pubmed/30301785 http://dx.doi.org/10.1084/jem.20181737 Text en © 2018 Deczkowska and Schwartz http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Viewpoint
Deczkowska, Aleksandra
Schwartz, Michal
Targeting neuro–immune communication in neurodegeneration: Challenges and opportunities
title Targeting neuro–immune communication in neurodegeneration: Challenges and opportunities
title_full Targeting neuro–immune communication in neurodegeneration: Challenges and opportunities
title_fullStr Targeting neuro–immune communication in neurodegeneration: Challenges and opportunities
title_full_unstemmed Targeting neuro–immune communication in neurodegeneration: Challenges and opportunities
title_short Targeting neuro–immune communication in neurodegeneration: Challenges and opportunities
title_sort targeting neuro–immune communication in neurodegeneration: challenges and opportunities
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219738/
https://www.ncbi.nlm.nih.gov/pubmed/30301785
http://dx.doi.org/10.1084/jem.20181737
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