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T-bet in Tfh cells: Now you see me, now you don’t
In this issue, Fang et al. (https://doi.org/10.1084/jem.20180927) report on a subset of T follicular helper (Tfh) cells that transiently expresses T-bet yet continues to produce IFN-γ at late stages of GC reactions following immunization. They find other genes uniquely expressed in this IFN-γ–produc...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219747/ https://www.ncbi.nlm.nih.gov/pubmed/30337467 http://dx.doi.org/10.1084/jem.20181878 |
| Sumario: | In this issue, Fang et al. (https://doi.org/10.1084/jem.20180927) report on a subset of T follicular helper (Tfh) cells that transiently expresses T-bet yet continues to produce IFN-γ at late stages of GC reactions following immunization. They find other genes uniquely expressed in this IFN-γ–producing Tfh subset, such as NKG2D, that can be used to better distinguish these functionally distinct Tfh cells. |
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