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Discriminatory performance of adiponectin and leptin in the identification of impaired glucose tolerance: The Guangzhou Biobank Cohort Study - Cardiovascular Disease Subcohort

BACKGROUND: To evaluate the additional discriminatory performance of adiponectin, leptin, and their ratio in the identification of impaired glucose tolerance (IGT) in men and women without diabetes on top of conventional risk factors. METHODS & RESULTS: A total of 698 subjects underwent an oral...

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Autores principales: Toulis, Konstantinos A., Jiang, Chao Q., Hemming, Karla, Nirantharakumar, Krishnarajah, Cheng, Kar K., Lam, Tai H., Thomas, G. Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219800/
https://www.ncbi.nlm.nih.gov/pubmed/30399195
http://dx.doi.org/10.1371/journal.pone.0206964
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author Toulis, Konstantinos A.
Jiang, Chao Q.
Hemming, Karla
Nirantharakumar, Krishnarajah
Cheng, Kar K.
Lam, Tai H.
Thomas, G. Neil
author_facet Toulis, Konstantinos A.
Jiang, Chao Q.
Hemming, Karla
Nirantharakumar, Krishnarajah
Cheng, Kar K.
Lam, Tai H.
Thomas, G. Neil
author_sort Toulis, Konstantinos A.
collection PubMed
description BACKGROUND: To evaluate the additional discriminatory performance of adiponectin, leptin, and their ratio in the identification of impaired glucose tolerance (IGT) in men and women without diabetes on top of conventional risk factors. METHODS & RESULTS: A total of 698 subjects underwent an oral glucose tolerance test (oGTT) and adipocytokine measurements. A comprehensive stepwise selection procedure was performed, followed by c-statistics and integrated discrimination improvement (IDI) analysis. In males, adiponectin levels were significantly lower in the IGT group compared to the non-IGT group (Whitney U test, p < 10–4), whereas leptin levels were significantly higher (p = 0.009) in IGT group. In females, adiponectin and leptin levels were not significantly different between groups (Mann-Whitney U test, p = 0.073 and p = 0.08, respectively). Adjusting for the most informative, sex-specific, clinical and biochemical factors, adiponectin, leptin and their ratio were not found to be significant predictors of the response to the glucose load, when modelled as continuous terms or tertiles. In males, the area-under-the-curve (AUC) for adiponectin was estimated at 0.620 (95% CI: 0.558–0.682) and the addition of adiponectin into the basic model provided a ΔAUC benefit of 0.004, showing no additional discriminatory benefit on top of conventional risk factors (IDI p-value: 0.27), nor did the addition of leptin or their ratio. The results were similar in females. CONCLUSIONS: In Chinese individuals without diabetes, no significant evidence for the potential discriminatory value of adiponectin, leptin or their ratio in the identification of IGT on top of conventional risk factors was observed.
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spelling pubmed-62198002018-11-19 Discriminatory performance of adiponectin and leptin in the identification of impaired glucose tolerance: The Guangzhou Biobank Cohort Study - Cardiovascular Disease Subcohort Toulis, Konstantinos A. Jiang, Chao Q. Hemming, Karla Nirantharakumar, Krishnarajah Cheng, Kar K. Lam, Tai H. Thomas, G. Neil PLoS One Research Article BACKGROUND: To evaluate the additional discriminatory performance of adiponectin, leptin, and their ratio in the identification of impaired glucose tolerance (IGT) in men and women without diabetes on top of conventional risk factors. METHODS & RESULTS: A total of 698 subjects underwent an oral glucose tolerance test (oGTT) and adipocytokine measurements. A comprehensive stepwise selection procedure was performed, followed by c-statistics and integrated discrimination improvement (IDI) analysis. In males, adiponectin levels were significantly lower in the IGT group compared to the non-IGT group (Whitney U test, p < 10–4), whereas leptin levels were significantly higher (p = 0.009) in IGT group. In females, adiponectin and leptin levels were not significantly different between groups (Mann-Whitney U test, p = 0.073 and p = 0.08, respectively). Adjusting for the most informative, sex-specific, clinical and biochemical factors, adiponectin, leptin and their ratio were not found to be significant predictors of the response to the glucose load, when modelled as continuous terms or tertiles. In males, the area-under-the-curve (AUC) for adiponectin was estimated at 0.620 (95% CI: 0.558–0.682) and the addition of adiponectin into the basic model provided a ΔAUC benefit of 0.004, showing no additional discriminatory benefit on top of conventional risk factors (IDI p-value: 0.27), nor did the addition of leptin or their ratio. The results were similar in females. CONCLUSIONS: In Chinese individuals without diabetes, no significant evidence for the potential discriminatory value of adiponectin, leptin or their ratio in the identification of IGT on top of conventional risk factors was observed. Public Library of Science 2018-11-06 /pmc/articles/PMC6219800/ /pubmed/30399195 http://dx.doi.org/10.1371/journal.pone.0206964 Text en © 2018 Toulis et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Toulis, Konstantinos A.
Jiang, Chao Q.
Hemming, Karla
Nirantharakumar, Krishnarajah
Cheng, Kar K.
Lam, Tai H.
Thomas, G. Neil
Discriminatory performance of adiponectin and leptin in the identification of impaired glucose tolerance: The Guangzhou Biobank Cohort Study - Cardiovascular Disease Subcohort
title Discriminatory performance of adiponectin and leptin in the identification of impaired glucose tolerance: The Guangzhou Biobank Cohort Study - Cardiovascular Disease Subcohort
title_full Discriminatory performance of adiponectin and leptin in the identification of impaired glucose tolerance: The Guangzhou Biobank Cohort Study - Cardiovascular Disease Subcohort
title_fullStr Discriminatory performance of adiponectin and leptin in the identification of impaired glucose tolerance: The Guangzhou Biobank Cohort Study - Cardiovascular Disease Subcohort
title_full_unstemmed Discriminatory performance of adiponectin and leptin in the identification of impaired glucose tolerance: The Guangzhou Biobank Cohort Study - Cardiovascular Disease Subcohort
title_short Discriminatory performance of adiponectin and leptin in the identification of impaired glucose tolerance: The Guangzhou Biobank Cohort Study - Cardiovascular Disease Subcohort
title_sort discriminatory performance of adiponectin and leptin in the identification of impaired glucose tolerance: the guangzhou biobank cohort study - cardiovascular disease subcohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219800/
https://www.ncbi.nlm.nih.gov/pubmed/30399195
http://dx.doi.org/10.1371/journal.pone.0206964
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