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Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse

The neonatal brain undergoes rapid maturational changes that facilitate the normal development of the nervous system and also affect the pathological response to brain injury. Electroencephalography (EEG) and analysis of sleep-wake vigilance states provide important insights into the function of the...

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Autores principales: Rensing, Nicholas, Moy, Brianna, Friedman, Joseph L., Galindo, Rafael, Wong, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219806/
https://www.ncbi.nlm.nih.gov/pubmed/30399187
http://dx.doi.org/10.1371/journal.pone.0207031
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author Rensing, Nicholas
Moy, Brianna
Friedman, Joseph L.
Galindo, Rafael
Wong, Michael
author_facet Rensing, Nicholas
Moy, Brianna
Friedman, Joseph L.
Galindo, Rafael
Wong, Michael
author_sort Rensing, Nicholas
collection PubMed
description The neonatal brain undergoes rapid maturational changes that facilitate the normal development of the nervous system and also affect the pathological response to brain injury. Electroencephalography (EEG) and analysis of sleep-wake vigilance states provide important insights into the function of the normal and diseased immature brain. While developmental changes in EEG and vigilance states are well-described in people, less is known about the normal maturational properties of rodent EEG, including the emergence and evolution of sleep-awake vigilance states. In particular, a number of developmental EEG studies have been performed in rats, but there is limited comparable research in neonatal mice, especially as it pertains to longitudinal EEG studies performed within the same mouse. In this study, we have attempted to provide a relatively comprehensive assessment of developmental changes in EEG background activity and vigilance states in wild-type mice from postnatal days 9–21. A novel EEG and EMG method allowed serial recording from the same mouse pups. EEG continuity and power and vigilance states were analyzed by quantitative assessment and fast Fourier transforms. During this developmental period, we demonstrate the timing of maturational changes in EEG background continuity, frequencies, and power and the emergence of identifiable wake, NREM, and REM sleep states. These results should serve as important control data for physiological studies of mouse models of normal brain development and neurological disease.
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spelling pubmed-62198062018-11-19 Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse Rensing, Nicholas Moy, Brianna Friedman, Joseph L. Galindo, Rafael Wong, Michael PLoS One Research Article The neonatal brain undergoes rapid maturational changes that facilitate the normal development of the nervous system and also affect the pathological response to brain injury. Electroencephalography (EEG) and analysis of sleep-wake vigilance states provide important insights into the function of the normal and diseased immature brain. While developmental changes in EEG and vigilance states are well-described in people, less is known about the normal maturational properties of rodent EEG, including the emergence and evolution of sleep-awake vigilance states. In particular, a number of developmental EEG studies have been performed in rats, but there is limited comparable research in neonatal mice, especially as it pertains to longitudinal EEG studies performed within the same mouse. In this study, we have attempted to provide a relatively comprehensive assessment of developmental changes in EEG background activity and vigilance states in wild-type mice from postnatal days 9–21. A novel EEG and EMG method allowed serial recording from the same mouse pups. EEG continuity and power and vigilance states were analyzed by quantitative assessment and fast Fourier transforms. During this developmental period, we demonstrate the timing of maturational changes in EEG background continuity, frequencies, and power and the emergence of identifiable wake, NREM, and REM sleep states. These results should serve as important control data for physiological studies of mouse models of normal brain development and neurological disease. Public Library of Science 2018-11-06 /pmc/articles/PMC6219806/ /pubmed/30399187 http://dx.doi.org/10.1371/journal.pone.0207031 Text en © 2018 Rensing et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Rensing, Nicholas
Moy, Brianna
Friedman, Joseph L.
Galindo, Rafael
Wong, Michael
Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse
title Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse
title_full Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse
title_fullStr Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse
title_full_unstemmed Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse
title_short Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse
title_sort longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219806/
https://www.ncbi.nlm.nih.gov/pubmed/30399187
http://dx.doi.org/10.1371/journal.pone.0207031
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