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Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse
The neonatal brain undergoes rapid maturational changes that facilitate the normal development of the nervous system and also affect the pathological response to brain injury. Electroencephalography (EEG) and analysis of sleep-wake vigilance states provide important insights into the function of the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219806/ https://www.ncbi.nlm.nih.gov/pubmed/30399187 http://dx.doi.org/10.1371/journal.pone.0207031 |
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author | Rensing, Nicholas Moy, Brianna Friedman, Joseph L. Galindo, Rafael Wong, Michael |
author_facet | Rensing, Nicholas Moy, Brianna Friedman, Joseph L. Galindo, Rafael Wong, Michael |
author_sort | Rensing, Nicholas |
collection | PubMed |
description | The neonatal brain undergoes rapid maturational changes that facilitate the normal development of the nervous system and also affect the pathological response to brain injury. Electroencephalography (EEG) and analysis of sleep-wake vigilance states provide important insights into the function of the normal and diseased immature brain. While developmental changes in EEG and vigilance states are well-described in people, less is known about the normal maturational properties of rodent EEG, including the emergence and evolution of sleep-awake vigilance states. In particular, a number of developmental EEG studies have been performed in rats, but there is limited comparable research in neonatal mice, especially as it pertains to longitudinal EEG studies performed within the same mouse. In this study, we have attempted to provide a relatively comprehensive assessment of developmental changes in EEG background activity and vigilance states in wild-type mice from postnatal days 9–21. A novel EEG and EMG method allowed serial recording from the same mouse pups. EEG continuity and power and vigilance states were analyzed by quantitative assessment and fast Fourier transforms. During this developmental period, we demonstrate the timing of maturational changes in EEG background continuity, frequencies, and power and the emergence of identifiable wake, NREM, and REM sleep states. These results should serve as important control data for physiological studies of mouse models of normal brain development and neurological disease. |
format | Online Article Text |
id | pubmed-6219806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-62198062018-11-19 Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse Rensing, Nicholas Moy, Brianna Friedman, Joseph L. Galindo, Rafael Wong, Michael PLoS One Research Article The neonatal brain undergoes rapid maturational changes that facilitate the normal development of the nervous system and also affect the pathological response to brain injury. Electroencephalography (EEG) and analysis of sleep-wake vigilance states provide important insights into the function of the normal and diseased immature brain. While developmental changes in EEG and vigilance states are well-described in people, less is known about the normal maturational properties of rodent EEG, including the emergence and evolution of sleep-awake vigilance states. In particular, a number of developmental EEG studies have been performed in rats, but there is limited comparable research in neonatal mice, especially as it pertains to longitudinal EEG studies performed within the same mouse. In this study, we have attempted to provide a relatively comprehensive assessment of developmental changes in EEG background activity and vigilance states in wild-type mice from postnatal days 9–21. A novel EEG and EMG method allowed serial recording from the same mouse pups. EEG continuity and power and vigilance states were analyzed by quantitative assessment and fast Fourier transforms. During this developmental period, we demonstrate the timing of maturational changes in EEG background continuity, frequencies, and power and the emergence of identifiable wake, NREM, and REM sleep states. These results should serve as important control data for physiological studies of mouse models of normal brain development and neurological disease. Public Library of Science 2018-11-06 /pmc/articles/PMC6219806/ /pubmed/30399187 http://dx.doi.org/10.1371/journal.pone.0207031 Text en © 2018 Rensing et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Rensing, Nicholas Moy, Brianna Friedman, Joseph L. Galindo, Rafael Wong, Michael Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse |
title | Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse |
title_full | Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse |
title_fullStr | Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse |
title_full_unstemmed | Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse |
title_short | Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse |
title_sort | longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219806/ https://www.ncbi.nlm.nih.gov/pubmed/30399187 http://dx.doi.org/10.1371/journal.pone.0207031 |
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