Disruption of CTCF-YY1–dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription

The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted. Upon epithelial differentiation, E6/E7 transcription is increased through unknown mechanisms to drive cellular prolif...

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Detalles Bibliográficos
Autores principales: Pentland, Ieisha, Campos-León, Karen, Cotic, Marius, Davies, Kelli-Jo, Wood, C. David, Groves, Ian J., Burley, Megan, Coleman, Nicholas, Stockton, Joanne D., Noyvert, Boris, Beggs, Andrew D., West, Michelle J., Roberts, Sally, Parish, Joanna L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219814/
https://www.ncbi.nlm.nih.gov/pubmed/30359362
http://dx.doi.org/10.1371/journal.pbio.2005752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219814/
https://www.ncbi.nlm.nih.gov/pubmed/30359362
http://dx.doi.org/10.1371/journal.pbio.2005752

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