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Disruption of CTCF-YY1–dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription
The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted. Upon epithelial differentiation, E6/E7 transcription is increased through unknown mechanisms to drive cellular prolif...
Autores principales: | Pentland, Ieisha, Campos-León, Karen, Cotic, Marius, Davies, Kelli-Jo, Wood, C. David, Groves, Ian J., Burley, Megan, Coleman, Nicholas, Stockton, Joanne D., Noyvert, Boris, Beggs, Andrew D., West, Michelle J., Roberts, Sally, Parish, Joanna L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219814/ https://www.ncbi.nlm.nih.gov/pubmed/30359362 http://dx.doi.org/10.1371/journal.pbio.2005752 |
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