Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1–mediated endocytosis

Matrix protease activity is fundamental to developmental tissue patterning and remains influential in adult homeostasis. In cartilage, the principal matrix proteoglycan is aggrecan, the protease-mediated catabolism of which defines arthritis; however, the pathophysiologic mechanisms that drive aberr...

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Detalles Bibliográficos
Autores principales: Coveney, Clarissa R., Collins, Isabella, Mc Fie, Megan, Chanalaris, Anastasios, Yamamoto, Kazuhiro, Wann, Angus K. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219823/
https://www.ncbi.nlm.nih.gov/pubmed/29920219
http://dx.doi.org/10.1096/fj.201800334

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