Cargando…

Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting

BACKGROUND: Maternal vaccines against pertussis are not yet recommended in the developing world. Besides unclear burden estimates, another concern is that transplacental transfer of maternal pertussis antibodies could result in attenuation of the immune response to whole cell pertussis (DTwP) primar...

Descripción completa

Detalles Bibliográficos
Autores principales: Ibrahim, Romesa, Ali, S. Asad, Kazi, A. Momin, Rizvi, Arjumand, Guterman, L. Beryl, Bednarczyk, Robert A., Kim, Ellie, Park, SoHee, Paulos, Simon, Jeyachandran, Amilia, Patel, Divya, Gorantla, Yamini, Wong, Emily, Rajam, Gowrisankar, Schiffer, Jarad, Omer, Saad B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219892/
https://www.ncbi.nlm.nih.gov/pubmed/30297122
http://dx.doi.org/10.1016/j.vaccine.2018.09.045
_version_ 1783368738186199040
author Ibrahim, Romesa
Ali, S. Asad
Kazi, A. Momin
Rizvi, Arjumand
Guterman, L. Beryl
Bednarczyk, Robert A.
Kim, Ellie
Park, SoHee
Paulos, Simon
Jeyachandran, Amilia
Patel, Divya
Gorantla, Yamini
Wong, Emily
Rajam, Gowrisankar
Schiffer, Jarad
Omer, Saad B.
author_facet Ibrahim, Romesa
Ali, S. Asad
Kazi, A. Momin
Rizvi, Arjumand
Guterman, L. Beryl
Bednarczyk, Robert A.
Kim, Ellie
Park, SoHee
Paulos, Simon
Jeyachandran, Amilia
Patel, Divya
Gorantla, Yamini
Wong, Emily
Rajam, Gowrisankar
Schiffer, Jarad
Omer, Saad B.
author_sort Ibrahim, Romesa
collection PubMed
description BACKGROUND: Maternal vaccines against pertussis are not yet recommended in the developing world. Besides unclear burden estimates, another concern is that transplacental transfer of maternal pertussis antibodies could result in attenuation of the immune response to whole cell pertussis (DTwP) primary vaccination series in infants. This study was taken up to determine whether higher levels of maternal pertussis antibodies attenuate immune response of infants to DTwP vaccination series given at 6–10–14 weeks of age. METHODOLOGY: A total of 261 pregnant women and their infants from four low-income settlements in Karachi, Pakistan were enrolled in this study. The study endpoints were infant antibody titers for Pertussis toxin (PTx), Filamentous hemagglutinin antigen (FHA), Pertactin (PRN) and Fimbriae type 2/3 (FIM) – from birth through 18 weeks of age. Cord blood or pre-vaccine pertussis antibody titers indicate the concentration of maternal antibodies transferred to infants. Linear regression models were used to determine the association between higher maternal antibody titers and infant immune response to DTwP vaccine. Geometric Mean Ratio (GMR) was calculated as the ratio of infant antibody titers at specified time points against the maternal antibody titers at the time of delivery. RESULTS: At eighteen weeks of age, the adjusted β regression coefficient for PTx was 0.06 (95% CI: -0.49-0.61), FHA 0.02 (95% CI: -0.26 -0.29), PRN 0.02 (95%CI -0.38- 0.43), and FIM 0.17 (95%CI: -0.21-0.54). Among infants who received at least two doses of DTwP vaccine, higher maternal antibody titers did not have any attenuating effect on infant post-immunization antibody titers against all four pertussis antigens. CONCLUSION: Maternal pertussis antibodies did not attenuate infant’s immune response to pertussis antigens in DTwP primary vaccine given at 6–10–14 weeks of age.
format Online
Article
Text
id pubmed-6219892
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elsevier Science
record_format MEDLINE/PubMed
spelling pubmed-62198922018-11-12 Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting Ibrahim, Romesa Ali, S. Asad Kazi, A. Momin Rizvi, Arjumand Guterman, L. Beryl Bednarczyk, Robert A. Kim, Ellie Park, SoHee Paulos, Simon Jeyachandran, Amilia Patel, Divya Gorantla, Yamini Wong, Emily Rajam, Gowrisankar Schiffer, Jarad Omer, Saad B. Vaccine Article BACKGROUND: Maternal vaccines against pertussis are not yet recommended in the developing world. Besides unclear burden estimates, another concern is that transplacental transfer of maternal pertussis antibodies could result in attenuation of the immune response to whole cell pertussis (DTwP) primary vaccination series in infants. This study was taken up to determine whether higher levels of maternal pertussis antibodies attenuate immune response of infants to DTwP vaccination series given at 6–10–14 weeks of age. METHODOLOGY: A total of 261 pregnant women and their infants from four low-income settlements in Karachi, Pakistan were enrolled in this study. The study endpoints were infant antibody titers for Pertussis toxin (PTx), Filamentous hemagglutinin antigen (FHA), Pertactin (PRN) and Fimbriae type 2/3 (FIM) – from birth through 18 weeks of age. Cord blood or pre-vaccine pertussis antibody titers indicate the concentration of maternal antibodies transferred to infants. Linear regression models were used to determine the association between higher maternal antibody titers and infant immune response to DTwP vaccine. Geometric Mean Ratio (GMR) was calculated as the ratio of infant antibody titers at specified time points against the maternal antibody titers at the time of delivery. RESULTS: At eighteen weeks of age, the adjusted β regression coefficient for PTx was 0.06 (95% CI: -0.49-0.61), FHA 0.02 (95% CI: -0.26 -0.29), PRN 0.02 (95%CI -0.38- 0.43), and FIM 0.17 (95%CI: -0.21-0.54). Among infants who received at least two doses of DTwP vaccine, higher maternal antibody titers did not have any attenuating effect on infant post-immunization antibody titers against all four pertussis antigens. CONCLUSION: Maternal pertussis antibodies did not attenuate infant’s immune response to pertussis antigens in DTwP primary vaccine given at 6–10–14 weeks of age. Elsevier Science 2018-11-12 /pmc/articles/PMC6219892/ /pubmed/30297122 http://dx.doi.org/10.1016/j.vaccine.2018.09.045 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ibrahim, Romesa
Ali, S. Asad
Kazi, A. Momin
Rizvi, Arjumand
Guterman, L. Beryl
Bednarczyk, Robert A.
Kim, Ellie
Park, SoHee
Paulos, Simon
Jeyachandran, Amilia
Patel, Divya
Gorantla, Yamini
Wong, Emily
Rajam, Gowrisankar
Schiffer, Jarad
Omer, Saad B.
Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting
title Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting
title_full Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting
title_fullStr Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting
title_full_unstemmed Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting
title_short Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting
title_sort impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219892/
https://www.ncbi.nlm.nih.gov/pubmed/30297122
http://dx.doi.org/10.1016/j.vaccine.2018.09.045
work_keys_str_mv AT ibrahimromesa impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT alisasad impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT kaziamomin impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT rizviarjumand impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT gutermanlberyl impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT bednarczykroberta impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT kimellie impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT parksohee impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT paulossimon impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT jeyachandranamilia impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT pateldivya impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT gorantlayamini impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT wongemily impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT rajamgowrisankar impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT schifferjarad impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting
AT omersaadb impactofmaternallyderivedpertussisantibodytitersoninfantwholecellpertussisvaccineresponseinalowincomesetting