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Flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-LEDs and electrodes

In this paper, a polyimide-based flexible device that integrates 16 micro-LEDs and 16 IrO(x)-modified microelectrodes for synchronous photostimulation and neural signal recording is presented. The 4 × 4 micro-LEDs (dimensions of 220 × 270 × 50 μm(3), 700 μm pitch) are fixed in the SU-8 fence structu...

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Autores principales: Ji, Bowen, Guo, Zhejun, Wang, Minghao, Yang, Bin, Wang, Xiaolin, Li, Wen, Liu, Jingquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220173/
https://www.ncbi.nlm.nih.gov/pubmed/31057915
http://dx.doi.org/10.1038/s41378-018-0027-0
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author Ji, Bowen
Guo, Zhejun
Wang, Minghao
Yang, Bin
Wang, Xiaolin
Li, Wen
Liu, Jingquan
author_facet Ji, Bowen
Guo, Zhejun
Wang, Minghao
Yang, Bin
Wang, Xiaolin
Li, Wen
Liu, Jingquan
author_sort Ji, Bowen
collection PubMed
description In this paper, a polyimide-based flexible device that integrates 16 micro-LEDs and 16 IrO(x)-modified microelectrodes for synchronous photostimulation and neural signal recording is presented. The 4 × 4 micro-LEDs (dimensions of 220 × 270 × 50 μm(3), 700 μm pitch) are fixed in the SU-8 fence structure on a polyimide substrate and connected to the leads via a wire-bonding method. The recording electrodes share a similar fabrication process on the polyimide with 16 microelectrode sites (200 μm in diameter and 700 μm in pitch) modified by iridium oxide (IrO(x)). These two subparts can be aligned with alignment holes and glued back-to-back by epoxy, which ensures that the light from the LEDs passes through the corresponding holes that are evenly distributed around the recording sites. The long-term electrical and optical stabilities of the device are verified using a soaking test for 3 months, and the thermal property is specifically studied with different duty cycles, voltages, and frequencies. Additionally, the electrochemical results prove the reliability of the IrO(x)-modified microelectrodes after repeated pressing or friction. To evaluate the tradeoff between flexibility and strength, two microelectrode arrays with thicknesses of 5 and 10 μm are evaluated through simulation and experiment. The proposed device can be a useful mapping optogenetics tool for neuroscience studies in small (rats and mice) and large animal subjects and ultimately in nonhuman primates.
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spelling pubmed-62201732019-05-03 Flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-LEDs and electrodes Ji, Bowen Guo, Zhejun Wang, Minghao Yang, Bin Wang, Xiaolin Li, Wen Liu, Jingquan Microsyst Nanoeng Article In this paper, a polyimide-based flexible device that integrates 16 micro-LEDs and 16 IrO(x)-modified microelectrodes for synchronous photostimulation and neural signal recording is presented. The 4 × 4 micro-LEDs (dimensions of 220 × 270 × 50 μm(3), 700 μm pitch) are fixed in the SU-8 fence structure on a polyimide substrate and connected to the leads via a wire-bonding method. The recording electrodes share a similar fabrication process on the polyimide with 16 microelectrode sites (200 μm in diameter and 700 μm in pitch) modified by iridium oxide (IrO(x)). These two subparts can be aligned with alignment holes and glued back-to-back by epoxy, which ensures that the light from the LEDs passes through the corresponding holes that are evenly distributed around the recording sites. The long-term electrical and optical stabilities of the device are verified using a soaking test for 3 months, and the thermal property is specifically studied with different duty cycles, voltages, and frequencies. Additionally, the electrochemical results prove the reliability of the IrO(x)-modified microelectrodes after repeated pressing or friction. To evaluate the tradeoff between flexibility and strength, two microelectrode arrays with thicknesses of 5 and 10 μm are evaluated through simulation and experiment. The proposed device can be a useful mapping optogenetics tool for neuroscience studies in small (rats and mice) and large animal subjects and ultimately in nonhuman primates. Nature Publishing Group UK 2018-10-08 /pmc/articles/PMC6220173/ /pubmed/31057915 http://dx.doi.org/10.1038/s41378-018-0027-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ji, Bowen
Guo, Zhejun
Wang, Minghao
Yang, Bin
Wang, Xiaolin
Li, Wen
Liu, Jingquan
Flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-LEDs and electrodes
title Flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-LEDs and electrodes
title_full Flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-LEDs and electrodes
title_fullStr Flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-LEDs and electrodes
title_full_unstemmed Flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-LEDs and electrodes
title_short Flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-LEDs and electrodes
title_sort flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-leds and electrodes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220173/
https://www.ncbi.nlm.nih.gov/pubmed/31057915
http://dx.doi.org/10.1038/s41378-018-0027-0
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