Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT i...

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Autores principales: Niemeijer, A. N., Leung, D., Huisman, M. C., Bahce, I., Hoekstra, O. S., van Dongen, G. A. M. S., Boellaard, R., Du, S., Hayes, W., Smith, R., Windhorst, A. D., Hendrikse, N. H., Poot, A., Vugts, D. J., Thunnissen, E., Morin, P., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M., de Gruijl, T. D., Smit, E. F., de Langen, A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220188/
https://www.ncbi.nlm.nih.gov/pubmed/30405135
http://dx.doi.org/10.1038/s41467-018-07131-y
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author Niemeijer, A. N.
Leung, D.
Huisman, M. C.
Bahce, I.
Hoekstra, O. S.
van Dongen, G. A. M. S.
Boellaard, R.
Du, S.
Hayes, W.
Smith, R.
Windhorst, A. D.
Hendrikse, N. H.
Poot, A.
Vugts, D. J.
Thunnissen, E.
Morin, P.
Lipovsek, D.
Donnelly, D. J.
Bonacorsi, S. J.
Velasquez, L. M.
de Gruijl, T. D.
Smit, E. F.
de Langen, A. J.
author_facet Niemeijer, A. N.
Leung, D.
Huisman, M. C.
Bahce, I.
Hoekstra, O. S.
van Dongen, G. A. M. S.
Boellaard, R.
Du, S.
Hayes, W.
Smith, R.
Windhorst, A. D.
Hendrikse, N. H.
Poot, A.
Vugts, D. J.
Thunnissen, E.
Morin, P.
Lipovsek, D.
Donnelly, D. J.
Bonacorsi, S. J.
Velasquez, L. M.
de Gruijl, T. D.
Smit, E. F.
de Langen, A. J.
author_sort Niemeijer, A. N.
collection PubMed
description PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions.
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spelling pubmed-62201882018-11-08 Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer Niemeijer, A. N. Leung, D. Huisman, M. C. Bahce, I. Hoekstra, O. S. van Dongen, G. A. M. S. Boellaard, R. Du, S. Hayes, W. Smith, R. Windhorst, A. D. Hendrikse, N. H. Poot, A. Vugts, D. J. Thunnissen, E. Morin, P. Lipovsek, D. Donnelly, D. J. Bonacorsi, S. J. Velasquez, L. M. de Gruijl, T. D. Smit, E. F. de Langen, A. J. Nat Commun Article PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions. Nature Publishing Group UK 2018-11-07 /pmc/articles/PMC6220188/ /pubmed/30405135 http://dx.doi.org/10.1038/s41467-018-07131-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Niemeijer, A. N.
Leung, D.
Huisman, M. C.
Bahce, I.
Hoekstra, O. S.
van Dongen, G. A. M. S.
Boellaard, R.
Du, S.
Hayes, W.
Smith, R.
Windhorst, A. D.
Hendrikse, N. H.
Poot, A.
Vugts, D. J.
Thunnissen, E.
Morin, P.
Lipovsek, D.
Donnelly, D. J.
Bonacorsi, S. J.
Velasquez, L. M.
de Gruijl, T. D.
Smit, E. F.
de Langen, A. J.
Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer
title Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer
title_full Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer
title_fullStr Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer
title_full_unstemmed Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer
title_short Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer
title_sort whole body pd-1 and pd-l1 positron emission tomography in patients with non-small-cell lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220188/
https://www.ncbi.nlm.nih.gov/pubmed/30405135
http://dx.doi.org/10.1038/s41467-018-07131-y
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