Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist

Non-native ligands for growth factor receptors that are generated by chemical synthesis are applicable to therapeutics. However, non-native ligands often regulate cellular signaling and biological responses in a different manner than native ligands. Generation of surrogate ligands comparable to nati...

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Detalles Bibliográficos
Autores principales: Miao, Wenyu, Sakai, Katsuya, Ozawa, Naoya, Nishiuchi, Takumi, Suzuki, Yoshinori, Ito, Kenichiro, Morioka, Tomomi, Umitsu, Masataka, Takagi, Junichi, Suga, Hiroaki, Matsumoto, Kunio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220203/
https://www.ncbi.nlm.nih.gov/pubmed/30405161
http://dx.doi.org/10.1038/s41598-018-34835-4

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