APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R

APOL1 risk alleles associate with chronic kidney disease in African Americans, but the mechanisms remain to be fully understood. We show that APOL1 risk alleles activate protein kinase R (PKR) in cultured cells and transgenic mice. This effect is preserved when a premature stop codon is introduced t...

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Detalles Bibliográficos
Autores principales: Okamoto, Koji, Rausch, Jason W., Wakashin, Hidefumi, Fu, Yulong, Chung, Joon-Yong, Dummer, Patrick D., Shin, Myung K., Chandra, Preeti, Suzuki, Kosuke, Shrivastav, Shashi, Rosenberg, Avi Z., Hewitt, Stephen M., Ray, Patricio E., Noiri, Eisei, Le Grice, Stuart F. J., Hoek, Maarten, Han, Zhe, Winkler, Cheryl A., Kopp, Jeffrey B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220249/
https://www.ncbi.nlm.nih.gov/pubmed/30417125
http://dx.doi.org/10.1038/s42003-018-0188-2

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