Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice

Mice lacking Sirt2 spontaneously develop tumors in multiple organs, as well as when expressed in combination with oncogenic Kras(G12D), leading to pancreatic tumors. Here, we report that after caerulein-induced pancreatitis, Sirt2-deficient mice exhibited an increased inflammatory phenotype and dela...

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Detalles Bibliográficos
Autores principales: Quan, Songhua, Principe, Daniel R., Dean, Angela E., Park, Seong-Hoon, Grippo, Paul J., Gius, David, Horikoshi, Nobuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220268/
https://www.ncbi.nlm.nih.gov/pubmed/30405152
http://dx.doi.org/10.1038/s41598-018-34792-y

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