Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation

Sox2 is a key transcriptional factor for maintaining pluripotency of stem cells. Sox2 deficiency causes neurodegeneration and impairs neurogenesis. Although the transcriptional regulation of Sox2 has been extensively studied, the mechanisms that control Sox2 protein turnover are yet to be clarified....

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Detalles Bibliográficos
Autores principales: Cui, Chun-Ping, Zhang, Yuan, Wang, Chanjuan, Yuan, Fang, Li, Hongchang, Yao, Yuying, Chen, Yuhan, Li, Chunnan, Wei, Wenyi, Liu, Cui Hua, He, Fuchu, Liu, Yan, Zhang, Lingqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220269/
https://www.ncbi.nlm.nih.gov/pubmed/30405104
http://dx.doi.org/10.1038/s41467-018-07025-z

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