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Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas

Proton minibeam radiation therapy (pMBRT) is a novel strategy which has already shown a remarkable reduction in neurotoxicity as to compared with standard proton therapy. Here we report on the first evaluation of tumor control effectiveness in glioma bearing rats with highly spatially modulated prot...

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Autores principales: Prezado, Yolanda, Jouvion, Gregory, Patriarca, Annalisa, Nauraye, Catherine, Guardiola, Consuelo, Juchaux, Marjorie, Lamirault, Charlotte, Labiod, Dalila, Jourdain, Laurene, Sebrie, Catherine, Dendale, Remi, Gonzalez, Wilfredo, Pouzoulet, Frederic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220274/
https://www.ncbi.nlm.nih.gov/pubmed/30405188
http://dx.doi.org/10.1038/s41598-018-34796-8
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author Prezado, Yolanda
Jouvion, Gregory
Patriarca, Annalisa
Nauraye, Catherine
Guardiola, Consuelo
Juchaux, Marjorie
Lamirault, Charlotte
Labiod, Dalila
Jourdain, Laurene
Sebrie, Catherine
Dendale, Remi
Gonzalez, Wilfredo
Pouzoulet, Frederic
author_facet Prezado, Yolanda
Jouvion, Gregory
Patriarca, Annalisa
Nauraye, Catherine
Guardiola, Consuelo
Juchaux, Marjorie
Lamirault, Charlotte
Labiod, Dalila
Jourdain, Laurene
Sebrie, Catherine
Dendale, Remi
Gonzalez, Wilfredo
Pouzoulet, Frederic
author_sort Prezado, Yolanda
collection PubMed
description Proton minibeam radiation therapy (pMBRT) is a novel strategy which has already shown a remarkable reduction in neurotoxicity as to compared with standard proton therapy. Here we report on the first evaluation of tumor control effectiveness in glioma bearing rats with highly spatially modulated proton beams. Whole brains (excluding the olfactory bulb) of Fischer 344 rats were irradiated. Four groups of animals were considered: a control group (RG2 tumor bearing rats), a second group of RG2 tumor-bearing rats and a third group of normal rats that received pMBRT (70 Gy peak dose in one fraction) with very heterogeneous dose distributions, and a control group of normal rats. The tumor-bearing and normal animals were followed-up for 6 months and one year, respectively. pMBRT leads to a significant tumor control and tumor eradication in 22% of the cases. No substantial brain damage which confirms the widening of the therapeutic window for high-grade gliomas offered by pMBRT. Additionally, the fact that large areas of the brain can be irradiated with pMBRT without significant side effects, would allow facing the infiltrative nature of gliomas.
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spelling pubmed-62202742018-11-08 Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas Prezado, Yolanda Jouvion, Gregory Patriarca, Annalisa Nauraye, Catherine Guardiola, Consuelo Juchaux, Marjorie Lamirault, Charlotte Labiod, Dalila Jourdain, Laurene Sebrie, Catherine Dendale, Remi Gonzalez, Wilfredo Pouzoulet, Frederic Sci Rep Article Proton minibeam radiation therapy (pMBRT) is a novel strategy which has already shown a remarkable reduction in neurotoxicity as to compared with standard proton therapy. Here we report on the first evaluation of tumor control effectiveness in glioma bearing rats with highly spatially modulated proton beams. Whole brains (excluding the olfactory bulb) of Fischer 344 rats were irradiated. Four groups of animals were considered: a control group (RG2 tumor bearing rats), a second group of RG2 tumor-bearing rats and a third group of normal rats that received pMBRT (70 Gy peak dose in one fraction) with very heterogeneous dose distributions, and a control group of normal rats. The tumor-bearing and normal animals were followed-up for 6 months and one year, respectively. pMBRT leads to a significant tumor control and tumor eradication in 22% of the cases. No substantial brain damage which confirms the widening of the therapeutic window for high-grade gliomas offered by pMBRT. Additionally, the fact that large areas of the brain can be irradiated with pMBRT without significant side effects, would allow facing the infiltrative nature of gliomas. Nature Publishing Group UK 2018-11-07 /pmc/articles/PMC6220274/ /pubmed/30405188 http://dx.doi.org/10.1038/s41598-018-34796-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Prezado, Yolanda
Jouvion, Gregory
Patriarca, Annalisa
Nauraye, Catherine
Guardiola, Consuelo
Juchaux, Marjorie
Lamirault, Charlotte
Labiod, Dalila
Jourdain, Laurene
Sebrie, Catherine
Dendale, Remi
Gonzalez, Wilfredo
Pouzoulet, Frederic
Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas
title Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas
title_full Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas
title_fullStr Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas
title_full_unstemmed Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas
title_short Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas
title_sort proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220274/
https://www.ncbi.nlm.nih.gov/pubmed/30405188
http://dx.doi.org/10.1038/s41598-018-34796-8
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