Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis

Activation of NF-κB signaling promotes osteoarthritis (OA) through the transcriptional induction of Hif-2α and catabolic enzymes. This study sought to examine whether inhibiting IκBα kinase (IKK) could suppress the development of surgically-induced OA of the knee in a mouse model. We employed BMS-34...

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Detalles Bibliográficos
Autores principales: Murahashi, Yasutaka, Yano, Fumiko, Kobayashi, Hiroshi, Makii, Yuma, Iba, Kousuke, Yamashita, Toshihiko, Tanaka, Sakae, Saito, Taku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220282/
https://www.ncbi.nlm.nih.gov/pubmed/30405206
http://dx.doi.org/10.1038/s41598-018-34830-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220282/
https://www.ncbi.nlm.nih.gov/pubmed/30405206
http://dx.doi.org/10.1038/s41598-018-34830-9

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