Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis

Hypoxia is a hallmark of solid tumours and a key physiological feature distinguishing cancer from normal tissue. However, a major challenge remains in identifying tractable molecular targets that hypoxic cancer cells depend on for survival. Here, we used SILAC‐based proteomics to identify the orphan...

Descripción completa

Detalles Bibliográficos
Autores principales: Greenhough, Alexander, Bagley, Clare, Heesom, Kate J, Gurevich, David B, Gay, David, Bond, Mark, Collard, Tracey J, Paraskeva, Chris, Martin, Paul, Sansom, Owen J, Malik, Karim, Williams, Ann C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220329/
https://www.ncbi.nlm.nih.gov/pubmed/30143543
http://dx.doi.org/10.15252/emmm.201708699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220329/
https://www.ncbi.nlm.nih.gov/pubmed/30143543
http://dx.doi.org/10.15252/emmm.201708699

Ejemplares similares