SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy

Histone deacetylase inhibitors (HDACi) can reverse chemoresistance, enhance chemotherapy-induced cytotoxicity, and reduce sarcoma proliferation in cell lines and animal models. We sought to determine the safety and toxicity of mocetinostat and its ability to reverse chemoresistance when administered...

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Detalles Bibliográficos
Autores principales: Choy, Edwin, Ballman, Karla, Chen, James, Dickson, Mark A., Chugh, Rashmi, George, Suzanne, Okuno, Scott, Pollock, Raphael, Patel, Rajiv M., Hoering, Antje, Patel, Shreyaskumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220374/
https://www.ncbi.nlm.nih.gov/pubmed/30473623
http://dx.doi.org/10.1155/2018/2068517

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