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HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases
High-mobility group box 1 (HMGB1) is a nuclear protein that can also act as an extracellular trigger of inflammation, proliferation, and migration in eye diseases. It induces signaling pathways by binding to the receptor for advanced glycation end products (RAGE) and Toll-like receptors (TLRs) 2, 4,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220384/ https://www.ncbi.nlm.nih.gov/pubmed/30473885 http://dx.doi.org/10.1155/2018/5195290 |
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author | Liu, Yi Zhuang, Guo-Bin Zhou, Xue-Zhi |
author_facet | Liu, Yi Zhuang, Guo-Bin Zhou, Xue-Zhi |
author_sort | Liu, Yi |
collection | PubMed |
description | High-mobility group box 1 (HMGB1) is a nuclear protein that can also act as an extracellular trigger of inflammation, proliferation, and migration in eye diseases. It induces signaling pathways by binding to the receptor for advanced glycation end products (RAGE) and Toll-like receptors (TLRs) 2, 4, and 9. This proinflammatory activity is considered to be important in the pathogenesis of a wide range of ocular diseases resulting from hemodynamic changes, presence of neovascular endothelial cells, secretion of intraocular immune factors or inflammation, and apoptosis of retinal cell layers. Further work is needed to elucidate in detail how HMGB1 contributes to ocular disease and how its damaging activity can be modulated. In this review, we summarize current knowledge on HMGB1 as a ligand that can evoke inflammation and immune responses in ocular diseases. |
format | Online Article Text |
id | pubmed-6220384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-62203842018-11-25 HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases Liu, Yi Zhuang, Guo-Bin Zhou, Xue-Zhi J Ophthalmol Review Article High-mobility group box 1 (HMGB1) is a nuclear protein that can also act as an extracellular trigger of inflammation, proliferation, and migration in eye diseases. It induces signaling pathways by binding to the receptor for advanced glycation end products (RAGE) and Toll-like receptors (TLRs) 2, 4, and 9. This proinflammatory activity is considered to be important in the pathogenesis of a wide range of ocular diseases resulting from hemodynamic changes, presence of neovascular endothelial cells, secretion of intraocular immune factors or inflammation, and apoptosis of retinal cell layers. Further work is needed to elucidate in detail how HMGB1 contributes to ocular disease and how its damaging activity can be modulated. In this review, we summarize current knowledge on HMGB1 as a ligand that can evoke inflammation and immune responses in ocular diseases. Hindawi 2018-10-24 /pmc/articles/PMC6220384/ /pubmed/30473885 http://dx.doi.org/10.1155/2018/5195290 Text en Copyright © 2018 Yi Liu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Liu, Yi Zhuang, Guo-Bin Zhou, Xue-Zhi HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases |
title | HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases |
title_full | HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases |
title_fullStr | HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases |
title_full_unstemmed | HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases |
title_short | HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases |
title_sort | hmbg1 as a driver of inflammatory and immune processes in the pathogenesis of ocular diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220384/ https://www.ncbi.nlm.nih.gov/pubmed/30473885 http://dx.doi.org/10.1155/2018/5195290 |
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