Stearyl polyethylenimine complexed with plasmids as the core of human serum albumin nanoparticles noncovalently bound to CRISPR/Cas9 plasmids or siRNA for disrupting or silencing PD-L1 expression for immunotherapy

PURPOSE: In this study, a double emulsion method for complexing plasmids with stearyl poly-ethylenimine (stPEI) as the core to form human serum albumin (HSA) (plasmid/stPEI/HSA) nanoparticles (NPs) was developed for gene delivery by non-covalently binding onto plasmid/stPEI/HSA nanoparticles with CR...

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Detalles Bibliográficos
Autores principales: Cheng, Wei-Jie, Chen, Ling-Chun, Ho, Hsiu-O, Lin, Hong-Liang, Sheu, Ming-Thau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220435/
https://www.ncbi.nlm.nih.gov/pubmed/30464460
http://dx.doi.org/10.2147/IJN.S181440

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