Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage

BACKGROUND: Neuroinflammation often develops in sepsis leading to activation of cerebral endothelium, increased permeability of the blood-brain barrier (BBB), and neutrophil infiltration. We have identified protein kinase C-delta (PKCδ) as a critical regulator of the inflammatory response and demons...

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Detalles Bibliográficos
Autores principales: Tang, Yuan, Soroush, Fariborz, Sun, Shuang, Liverani, Elisabetta, Langston, Jordan C., Yang, Qingliang, Kilpatrick, Laurie E., Kiani, Mohammad F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220469/
https://www.ncbi.nlm.nih.gov/pubmed/30400800
http://dx.doi.org/10.1186/s12974-018-1342-y

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