Cargando…

Partial, Rather than Full, BACE1 Inhibition May Be a Better Therapeutic Strategy for Alzheimer’s Disease Due to Effects of Complete Loss of BACE1 Activity on Adult Hippocampal Neurogenesis

Highlighted Research Paper: BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice by, Zena K. Chatila, Eunhee Kim, Clara Berlé, Enjana Bylykbashi, Alexander Rompala, Mary K. Oram, Drew Gupta, Sang Su Kwak, Young Hye Kim, Doo Yeon Kim, Se Hoon Ch...

Descripción completa

Detalles Bibliográficos
Autor principal:	Carney, Rosalind S.E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2018
Materias:	Feature: Research Highlights
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220578/ https://www.ncbi.nlm.nih.gov/pubmed/30406184 http://dx.doi.org/10.1523/ENEURO.0384-18.2018

Ejemplares similares

Spontaneous Brain Oscillations Induce Neuronal Excitability Changes That Affect Subjective Perception, Rather Than Decision-Making Strategy
por: Carney, Rosalind S. E.
Publicado: (2018)

Concurrent Medial Prefrontal Cortex and Dorsal Hippocampal Activity Is Required for Estradiol-Mediated Effects on Object Memory and Spatial Memory Consolidation
por: Carney, Rosalind S.E.
Publicado: (2019)

Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis
por: Modarresi, Farzaneh, et al.
Publicado: (2011)

fMRI Analysis of Brain Network Connectivity during Adolescence. Knowledge of Normotypic Brain Connectivity Patterns May Further Understanding of Aberrant Processes that Cause Psychiatric Illnesses
por: Carney, Rosalind S.E.
Publicado: (2018)

Neurocognitive and Synaptic Potentiation Deficits Are Mitigated by Inhibition of HIF1a Signaling following Intermittent Hypoxia in Rodents
por: Carney, Rosalind S.E.
Publicado: (2020)

An Emerging Role for RNA in a Memory-Like Behavioral Effect in Aplysia
por: Carney, Rosalind SE
Publicado: (2018)

Parallel and Sequential Sequences of Taste Detection and Discrimination in Humans
por: Carney, Rosalind SE
Publicado: (2019)

Neurofeedback Training Enables Voluntary Alteration of β-Band Power in the Subthalamic Nucleus of Individuals with Parkinson’s Disease
por: Carney, Rosalind SE
Publicado: (2019)

Is It the Twilight of BACE1 Inhibitors?
por: Hrabinova, Martina, et al.
Publicado: (2021)

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
por: Zhao, Yonghao, et al.
Publicado: (2012)

The effect of BACE1-AS on β-amyloid generation by regulating BACE1 mRNA expression
por: Li, Fan, et al.
Publicado: (2019)

Serotonin-Mediated Effects of Maternal Presence on Brain Activity in the Prefrontal Cortex of Pups: Implications for Maternal Neglect
por: Carney, Rosalind S.E.
Publicado: (2018)

Potential Protein Target to Therapeutically Restore Positive Mood States in Depression
por: Carney, Rosalind S.E.
Publicado: (2019)

How Do Drosophila Stay Awake during the Daytime? Dopaminergic Neurons Are Inhibited by the Pigment Dispersing Factor Signaling Pathway to Promote Wakefulness
por: Carney, Rosalind S.E.
Publicado: (2018)

Estrogen-Dominant Ovarian Cycle Stages Are Associated with Neural Network Dysfunction and Cognitive and Behavioral Deficits in the hAPP-J20 Mouse Model of Alzheimer’s Disease
por: Carney, Rosalind S.E.
Publicado: (2019)

Changes in Functional Brain Connectivity Highlight the Importance of a Baseline Measurement and Multiple Imaging Sessions for Cocaine Abstinence Studies
por: Carney, Rosalind S.E.
Publicado: (2018)

Identification of a Novel Molecular Target for Alcohol Dependence
por: Carney, Rosalind S.E.
Publicado: (2018)

Transplanted Human Induced Pluripotent Stem Cell-Derived Neurons Wire and Fire with Balanced Excitation–Inhibition in Rat Cortex
por: Carney, Rosalind S.E.
Publicado: (2020)

Astrocytes Function as an Intermediate for Retrograde Endocannabinoid Signaling in the Suprachiasmatic Nucleus to Influence Circadian Clock Timing
por: Carney, Rosalind S.E.
Publicado: (2020)

Does Prenatal Exposure to Maternal Inflammation Causes Sex Differences in Schizophrenia-Related Behavioral Outcomes in Adult Rats?
por: Carney, Rosalind S.E.
Publicado: (2019)

Ultrasonic Vocalizations Emitted during Defensive Behavior Alter the Influence of the Respiratory Rhythm on Brain Oscillatory Dynamics in the Fear Circuit of Rats
por: Carney, Rosalind S.E.
Publicado: (2019)

Differential Effects of Chronic Alcohol Consumption on Cortical and Subcortical Brain Volume in Adolescent Nonhuman Primates
por: Carney, Rosalind S.E.
Publicado: (2019)

Pharmacological Inactivation of Medial Prefrontal Cortex Does Not Support Dichotomous “Go/Stop” Roles for Dorsal and Ventral Subdivisions in Natural Reward Seeking in Rats
por: Carney, Rosalind S.E.
Publicado: (2020)

A tale of two drug targets: the evolutionary history of BACE1 and BACE2
por: Southan, Christopher, et al.
Publicado: (2013)

BACE1: More than just a β‐secretase
por: Taylor, Hannah A., et al.
Publicado: (2022)

BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats
por: Weber, Martin, et al.
Publicado: (2017)

RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation
por: Qiu, Kaixin, et al.
Publicado: (2020)

Developing BACE-1 inhibitors for FXS
por: Westmark, Cara J., et al.
Publicado: (2013)

Early elevation of BACE1 in dementia
por: Cervellati, Carlo, et al.
Publicado: (2021)

Amino Acid Sequence and Structural Comparison of BACE1 and BACE2 Using Evolutionary Trace Method
por: Mirsafian, Hoda, et al.
Publicado: (2014)

BACE1 and SCD1 are associated with neurodegeneration
por: Bedoya-Guzmán, Ferley A., et al.
Publicado: (2023)

BACE1 partial deletion induces synaptic plasticity deficit in adult mice
por: Lombardo, Sylvia, et al.
Publicado: (2019)

PS1 Affects the Pathology of Alzheimer’s Disease by Regulating BACE1 Distribution in the ER and BACE1 Maturation in the Golgi Apparatus
por: Li, Nuomin, et al.
Publicado: (2022)

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice
por: Shimshek, Derya R., et al.
Publicado: (2016)

Evaluation of BACE1 Silencing in Cellular Models
por: Sierant, Malgorzata, et al.
Publicado: (2009)

Regulation of dynamic BACE1 trafficking in neurons
por: Buggia-Prévot, Virginie, et al.
Publicado: (2013)

Development and Structural Modification of BACE1 Inhibitors
por: Gu, Ting, et al.
Publicado: (2016)

Role of BACE1 in Alzheimer’s synaptic function
por: Das, Brati, et al.
Publicado: (2017)

Expression of BACE1 in the Rat Carotid Body
por: Li, Chaohong, et al.
Publicado: (2020)

Attenuated ability of BACE1 to cleave the amyloid precursor protein via silencing long noncoding RNA BACE1-AS expression
por: LIU, TE, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_aqomntkro7pqv80u599odorba2