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Functional Categories of Visuomotor Neurons in Macaque Frontal Eye Field

Frontal eye field (FEF) in macaque monkeys contributes to visual attention, visual–motor transformations and production of eye movements. Traditionally, neurons in FEF have been classified by the magnitude of increased discharge rates following visual stimulus presentation, during a waiting period,...

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Autores principales: Lowe, Kaleb A., Schall, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220589/
https://www.ncbi.nlm.nih.gov/pubmed/30406195
http://dx.doi.org/10.1523/ENEURO.0131-18.2018
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author Lowe, Kaleb A.
Schall, Jeffrey D.
author_facet Lowe, Kaleb A.
Schall, Jeffrey D.
author_sort Lowe, Kaleb A.
collection PubMed
description Frontal eye field (FEF) in macaque monkeys contributes to visual attention, visual–motor transformations and production of eye movements. Traditionally, neurons in FEF have been classified by the magnitude of increased discharge rates following visual stimulus presentation, during a waiting period, and associated with eye movement production. However, considerable heterogeneity remains within the traditional visual, visuomovement, and movement categories. Cluster analysis is a data-driven method of identifying self-segregating groups within a dataset. Because many cluster analysis techniques exist and outcomes vary with analysis assumptions, consensus clustering aggregates over multiple analyses, identifying robust groups. To describe more comprehensively the neuronal composition of FEF, we applied a consensus clustering technique for unsupervised categorization of patterns of spike rate modulation measured during a memory-guided saccade task. We report 10 functional categories, expanding on the traditional 3 categories. Categories were distinguished by latency, magnitude, and sign of visual response; the presence of sustained activity; and the dynamics, magnitude and sign of saccade-related modulation. Consensus clustering can include other metrics and can be applied to datasets from other brain regions to provide better information guiding microcircuit models of cortical function.
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spelling pubmed-62205892018-11-07 Functional Categories of Visuomotor Neurons in Macaque Frontal Eye Field Lowe, Kaleb A. Schall, Jeffrey D. eNeuro Methods/New Tools Frontal eye field (FEF) in macaque monkeys contributes to visual attention, visual–motor transformations and production of eye movements. Traditionally, neurons in FEF have been classified by the magnitude of increased discharge rates following visual stimulus presentation, during a waiting period, and associated with eye movement production. However, considerable heterogeneity remains within the traditional visual, visuomovement, and movement categories. Cluster analysis is a data-driven method of identifying self-segregating groups within a dataset. Because many cluster analysis techniques exist and outcomes vary with analysis assumptions, consensus clustering aggregates over multiple analyses, identifying robust groups. To describe more comprehensively the neuronal composition of FEF, we applied a consensus clustering technique for unsupervised categorization of patterns of spike rate modulation measured during a memory-guided saccade task. We report 10 functional categories, expanding on the traditional 3 categories. Categories were distinguished by latency, magnitude, and sign of visual response; the presence of sustained activity; and the dynamics, magnitude and sign of saccade-related modulation. Consensus clustering can include other metrics and can be applied to datasets from other brain regions to provide better information guiding microcircuit models of cortical function. Society for Neuroscience 2018-10-17 /pmc/articles/PMC6220589/ /pubmed/30406195 http://dx.doi.org/10.1523/ENEURO.0131-18.2018 Text en Copyright © 2018 Lowe and Schall http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Methods/New Tools
Lowe, Kaleb A.
Schall, Jeffrey D.
Functional Categories of Visuomotor Neurons in Macaque Frontal Eye Field
title Functional Categories of Visuomotor Neurons in Macaque Frontal Eye Field
title_full Functional Categories of Visuomotor Neurons in Macaque Frontal Eye Field
title_fullStr Functional Categories of Visuomotor Neurons in Macaque Frontal Eye Field
title_full_unstemmed Functional Categories of Visuomotor Neurons in Macaque Frontal Eye Field
title_short Functional Categories of Visuomotor Neurons in Macaque Frontal Eye Field
title_sort functional categories of visuomotor neurons in macaque frontal eye field
topic Methods/New Tools
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220589/
https://www.ncbi.nlm.nih.gov/pubmed/30406195
http://dx.doi.org/10.1523/ENEURO.0131-18.2018
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