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Cancer and dementia: Two sides of the same coin?

Noncentral nervous system cancer and the brain share an interesting and complex relation, with an emerging body of evidence showing that cancer patients are at an increased risk of developing cognitive problems. In contrast, population‐based studies consistently find an inverse link between cancer a...

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Detalles Bibliográficos
Autores principales: van der Willik, Kimberly D., Schagen, Sanne B., Ikram, M. Arfan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220770/
https://www.ncbi.nlm.nih.gov/pubmed/30112764
http://dx.doi.org/10.1111/eci.13019
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author van der Willik, Kimberly D.
Schagen, Sanne B.
Ikram, M. Arfan
author_facet van der Willik, Kimberly D.
Schagen, Sanne B.
Ikram, M. Arfan
author_sort van der Willik, Kimberly D.
collection PubMed
description Noncentral nervous system cancer and the brain share an interesting and complex relation, with an emerging body of evidence showing that cancer patients are at an increased risk of developing cognitive problems. In contrast, population‐based studies consistently find an inverse link between cancer and dementia, that is patients with dementia having a lower risk of subsequently developing cancer, and cancer patients being less often diagnosed with dementia. Different biological processes such as inversely activated cell proliferation and survival pathways have been suggested to have an important role underlying this inverse association. However, the effect of methodological biases including surveillance or survival bias has not been completely ruled out, calling into question the inverse direction of the association between cancer and dementia. In fact, emerging evidence now suggests that cancer and dementia might share a positive association. This narrative review summarises the current literature on cancer, cognitive problems and dementia. Moreover, different strategies will be discussed to reduce the impact of potential methodological biases on the association between cancer and dementia, trying to reveal the true direction of this link.
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spelling pubmed-62207702018-11-13 Cancer and dementia: Two sides of the same coin? van der Willik, Kimberly D. Schagen, Sanne B. Ikram, M. Arfan Eur J Clin Invest Reviews Noncentral nervous system cancer and the brain share an interesting and complex relation, with an emerging body of evidence showing that cancer patients are at an increased risk of developing cognitive problems. In contrast, population‐based studies consistently find an inverse link between cancer and dementia, that is patients with dementia having a lower risk of subsequently developing cancer, and cancer patients being less often diagnosed with dementia. Different biological processes such as inversely activated cell proliferation and survival pathways have been suggested to have an important role underlying this inverse association. However, the effect of methodological biases including surveillance or survival bias has not been completely ruled out, calling into question the inverse direction of the association between cancer and dementia. In fact, emerging evidence now suggests that cancer and dementia might share a positive association. This narrative review summarises the current literature on cancer, cognitive problems and dementia. Moreover, different strategies will be discussed to reduce the impact of potential methodological biases on the association between cancer and dementia, trying to reveal the true direction of this link. John Wiley and Sons Inc. 2018-08-31 2018-11 /pmc/articles/PMC6220770/ /pubmed/30112764 http://dx.doi.org/10.1111/eci.13019 Text en © 2018 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Reviews
van der Willik, Kimberly D.
Schagen, Sanne B.
Ikram, M. Arfan
Cancer and dementia: Two sides of the same coin?
title Cancer and dementia: Two sides of the same coin?
title_full Cancer and dementia: Two sides of the same coin?
title_fullStr Cancer and dementia: Two sides of the same coin?
title_full_unstemmed Cancer and dementia: Two sides of the same coin?
title_short Cancer and dementia: Two sides of the same coin?
title_sort cancer and dementia: two sides of the same coin?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220770/
https://www.ncbi.nlm.nih.gov/pubmed/30112764
http://dx.doi.org/10.1111/eci.13019
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