Synthesis of Structurally Diverse N‐Substituted Quaternary‐Carbon‐Containing Small Molecules from α,α‐Disubstituted Propargyl Amino Esters

N‐containing quaternary stereocenters represent important motifs in medicinal chemistry. However, due to their inherently sterically hindered nature, they remain underrepresented in small molecule screening collections. As such, the development of synthetic routes to generate small molecules that in...

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Detalles Bibliográficos
Autores principales: Mateu, Natalia, Kidd, Sarah L., Kalash, Leen, Sore, Hannah F., Madin, Andrew, Bender, Andreas, Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220872/
https://www.ncbi.nlm.nih.gov/pubmed/30011115
http://dx.doi.org/10.1002/chem.201803143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220872/
https://www.ncbi.nlm.nih.gov/pubmed/30011115
http://dx.doi.org/10.1002/chem.201803143

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