Targeting of Liver Mannan-Binding Lectin–Associated Serine Protease-3 with RNA Interference Ameliorates Disease in a Mouse Model of Rheumatoid Arthritis

Mannan-binding lectin–associated serine protease 3 (MASP-3) regulates the alternative pathway of complement and is predominantly synthesized in the liver. The role of liver-derived MASP-3 in the pathogenesis of rheumatoid arthritis (RA) is unknown. We hypothesized that liver-derived MASP-3 is essent...

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Detalles Bibliográficos
Autores principales: Banda, Nirmal K., Desai, Dhruv, Scheinman, Robert I., Pihl, Rasmus, Sekine, Hideharu, Fujita, Teizo, Sharma, Vibha, Hansen, Annette G., Garred, Peter, Thiel, Steffen, Borodovsky, Anna, Holers, V. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220895/
https://www.ncbi.nlm.nih.gov/pubmed/30417171
http://dx.doi.org/10.4049/immunohorizons.1800053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220895/
https://www.ncbi.nlm.nih.gov/pubmed/30417171
http://dx.doi.org/10.4049/immunohorizons.1800053

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