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Does cardiac development provide heart research with novel therapeutic approaches?
Embryonic heart progenitors arise at specific spatiotemporal periods that contribute to the formation of distinct cardiac structures. In mammals, the embryonic and fetal heart is hypoxic by comparison to the adult heart. In parallel, the cellular metabolism of the cardiac tissue, including progenito...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221076/ https://www.ncbi.nlm.nih.gov/pubmed/30450195 http://dx.doi.org/10.12688/f1000research.15609.1 |
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author | Sayed, Angeliqua Valente, Mariana Sassoon, David |
author_facet | Sayed, Angeliqua Valente, Mariana Sassoon, David |
author_sort | Sayed, Angeliqua |
collection | PubMed |
description | Embryonic heart progenitors arise at specific spatiotemporal periods that contribute to the formation of distinct cardiac structures. In mammals, the embryonic and fetal heart is hypoxic by comparison to the adult heart. In parallel, the cellular metabolism of the cardiac tissue, including progenitors, undergoes a glycolytic to oxidative switch that contributes to cardiac maturation. While oxidative metabolism is energy efficient, the glycolytic-hypoxic state may serve to maintain cardiac progenitor potential. Consistent with this proposal, the adult epicardium has been shown to contain a reservoir of quiescent cardiac progenitors that are activated in response to heart injury and are hypoxic by comparison to adjacent cardiac tissues. In this review, we discuss the development and potential of the adult epicardium and how this knowledge may provide future therapeutic approaches for cardiac repair. |
format | Online Article Text |
id | pubmed-6221076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-62210762018-11-15 Does cardiac development provide heart research with novel therapeutic approaches? Sayed, Angeliqua Valente, Mariana Sassoon, David F1000Res Review Embryonic heart progenitors arise at specific spatiotemporal periods that contribute to the formation of distinct cardiac structures. In mammals, the embryonic and fetal heart is hypoxic by comparison to the adult heart. In parallel, the cellular metabolism of the cardiac tissue, including progenitors, undergoes a glycolytic to oxidative switch that contributes to cardiac maturation. While oxidative metabolism is energy efficient, the glycolytic-hypoxic state may serve to maintain cardiac progenitor potential. Consistent with this proposal, the adult epicardium has been shown to contain a reservoir of quiescent cardiac progenitors that are activated in response to heart injury and are hypoxic by comparison to adjacent cardiac tissues. In this review, we discuss the development and potential of the adult epicardium and how this knowledge may provide future therapeutic approaches for cardiac repair. F1000 Research Limited 2018-11-06 /pmc/articles/PMC6221076/ /pubmed/30450195 http://dx.doi.org/10.12688/f1000research.15609.1 Text en Copyright: © 2018 Sayed A et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Sayed, Angeliqua Valente, Mariana Sassoon, David Does cardiac development provide heart research with novel therapeutic approaches? |
title | Does cardiac development provide heart research with novel therapeutic approaches? |
title_full | Does cardiac development provide heart research with novel therapeutic approaches? |
title_fullStr | Does cardiac development provide heart research with novel therapeutic approaches? |
title_full_unstemmed | Does cardiac development provide heart research with novel therapeutic approaches? |
title_short | Does cardiac development provide heart research with novel therapeutic approaches? |
title_sort | does cardiac development provide heart research with novel therapeutic approaches? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221076/ https://www.ncbi.nlm.nih.gov/pubmed/30450195 http://dx.doi.org/10.12688/f1000research.15609.1 |
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