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Does cardiac development provide heart research with novel therapeutic approaches?

Embryonic heart progenitors arise at specific spatiotemporal periods that contribute to the formation of distinct cardiac structures. In mammals, the embryonic and fetal heart is hypoxic by comparison to the adult heart. In parallel, the cellular metabolism of the cardiac tissue, including progenito...

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Detalles Bibliográficos
Autores principales: Sayed, Angeliqua, Valente, Mariana, Sassoon, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221076/
https://www.ncbi.nlm.nih.gov/pubmed/30450195
http://dx.doi.org/10.12688/f1000research.15609.1
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author Sayed, Angeliqua
Valente, Mariana
Sassoon, David
author_facet Sayed, Angeliqua
Valente, Mariana
Sassoon, David
author_sort Sayed, Angeliqua
collection PubMed
description Embryonic heart progenitors arise at specific spatiotemporal periods that contribute to the formation of distinct cardiac structures. In mammals, the embryonic and fetal heart is hypoxic by comparison to the adult heart. In parallel, the cellular metabolism of the cardiac tissue, including progenitors, undergoes a glycolytic to oxidative switch that contributes to cardiac maturation. While oxidative metabolism is energy efficient, the glycolytic-hypoxic state may serve to maintain cardiac progenitor potential. Consistent with this proposal, the adult epicardium has been shown to contain a reservoir of quiescent cardiac progenitors that are activated in response to heart injury and are hypoxic by comparison to adjacent cardiac tissues. In this review, we discuss the development and potential of the adult epicardium and how this knowledge may provide future therapeutic approaches for cardiac repair.
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spelling pubmed-62210762018-11-15 Does cardiac development provide heart research with novel therapeutic approaches? Sayed, Angeliqua Valente, Mariana Sassoon, David F1000Res Review Embryonic heart progenitors arise at specific spatiotemporal periods that contribute to the formation of distinct cardiac structures. In mammals, the embryonic and fetal heart is hypoxic by comparison to the adult heart. In parallel, the cellular metabolism of the cardiac tissue, including progenitors, undergoes a glycolytic to oxidative switch that contributes to cardiac maturation. While oxidative metabolism is energy efficient, the glycolytic-hypoxic state may serve to maintain cardiac progenitor potential. Consistent with this proposal, the adult epicardium has been shown to contain a reservoir of quiescent cardiac progenitors that are activated in response to heart injury and are hypoxic by comparison to adjacent cardiac tissues. In this review, we discuss the development and potential of the adult epicardium and how this knowledge may provide future therapeutic approaches for cardiac repair. F1000 Research Limited 2018-11-06 /pmc/articles/PMC6221076/ /pubmed/30450195 http://dx.doi.org/10.12688/f1000research.15609.1 Text en Copyright: © 2018 Sayed A et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Sayed, Angeliqua
Valente, Mariana
Sassoon, David
Does cardiac development provide heart research with novel therapeutic approaches?
title Does cardiac development provide heart research with novel therapeutic approaches?
title_full Does cardiac development provide heart research with novel therapeutic approaches?
title_fullStr Does cardiac development provide heart research with novel therapeutic approaches?
title_full_unstemmed Does cardiac development provide heart research with novel therapeutic approaches?
title_short Does cardiac development provide heart research with novel therapeutic approaches?
title_sort does cardiac development provide heart research with novel therapeutic approaches?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221076/
https://www.ncbi.nlm.nih.gov/pubmed/30450195
http://dx.doi.org/10.12688/f1000research.15609.1
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