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The role of Nrf2 signaling in counteracting neurodegenerative diseases
The transcription factor Nrf2 (nuclear factor‐erythroid 2 p45‐related factor 2) functions at the interface of cellular redox and intermediary metabolism. Nrf2 target genes encode antioxidant enzymes, and proteins involved in xenobiotic detoxification, repair and removal of damaged proteins and organ...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221096/ https://www.ncbi.nlm.nih.gov/pubmed/29323772 http://dx.doi.org/10.1111/febs.14379 |
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author | Dinkova‐Kostova, Albena T. Kostov, Rumen V. Kazantsev, Aleksey G. |
author_facet | Dinkova‐Kostova, Albena T. Kostov, Rumen V. Kazantsev, Aleksey G. |
author_sort | Dinkova‐Kostova, Albena T. |
collection | PubMed |
description | The transcription factor Nrf2 (nuclear factor‐erythroid 2 p45‐related factor 2) functions at the interface of cellular redox and intermediary metabolism. Nrf2 target genes encode antioxidant enzymes, and proteins involved in xenobiotic detoxification, repair and removal of damaged proteins and organelles, inflammation, and mitochondrial bioenergetics. The function of Nrf2 is altered in many neurodegenerative disorders, such as Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and Friedreich's ataxia. Nrf2 activation mitigates multiple pathogenic processes involved in these neurodegenerative disorders through upregulation of antioxidant defenses, inhibition of inflammation, improvement of mitochondrial function, and maintenance of protein homeostasis. Small molecule pharmacological activators of Nrf2 have shown protective effects in numerous animal models of neurodegenerative diseases, and in cultures of human cells expressing mutant proteins. Targeting Nrf2 signaling may provide a therapeutic option to delay onset, slow progression, and ameliorate symptoms of neurodegenerative disorders. |
format | Online Article Text |
id | pubmed-6221096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62210962018-11-15 The role of Nrf2 signaling in counteracting neurodegenerative diseases Dinkova‐Kostova, Albena T. Kostov, Rumen V. Kazantsev, Aleksey G. FEBS J Review Articles The transcription factor Nrf2 (nuclear factor‐erythroid 2 p45‐related factor 2) functions at the interface of cellular redox and intermediary metabolism. Nrf2 target genes encode antioxidant enzymes, and proteins involved in xenobiotic detoxification, repair and removal of damaged proteins and organelles, inflammation, and mitochondrial bioenergetics. The function of Nrf2 is altered in many neurodegenerative disorders, such as Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and Friedreich's ataxia. Nrf2 activation mitigates multiple pathogenic processes involved in these neurodegenerative disorders through upregulation of antioxidant defenses, inhibition of inflammation, improvement of mitochondrial function, and maintenance of protein homeostasis. Small molecule pharmacological activators of Nrf2 have shown protective effects in numerous animal models of neurodegenerative diseases, and in cultures of human cells expressing mutant proteins. Targeting Nrf2 signaling may provide a therapeutic option to delay onset, slow progression, and ameliorate symptoms of neurodegenerative disorders. John Wiley and Sons Inc. 2018-01-29 2018-10 /pmc/articles/PMC6221096/ /pubmed/29323772 http://dx.doi.org/10.1111/febs.14379 Text en © 2018 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Dinkova‐Kostova, Albena T. Kostov, Rumen V. Kazantsev, Aleksey G. The role of Nrf2 signaling in counteracting neurodegenerative diseases |
title | The role of Nrf2 signaling in counteracting neurodegenerative diseases |
title_full | The role of Nrf2 signaling in counteracting neurodegenerative diseases |
title_fullStr | The role of Nrf2 signaling in counteracting neurodegenerative diseases |
title_full_unstemmed | The role of Nrf2 signaling in counteracting neurodegenerative diseases |
title_short | The role of Nrf2 signaling in counteracting neurodegenerative diseases |
title_sort | role of nrf2 signaling in counteracting neurodegenerative diseases |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221096/ https://www.ncbi.nlm.nih.gov/pubmed/29323772 http://dx.doi.org/10.1111/febs.14379 |
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