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The role of Nrf2 signaling in counteracting neurodegenerative diseases

The transcription factor Nrf2 (nuclear factor‐erythroid 2 p45‐related factor 2) functions at the interface of cellular redox and intermediary metabolism. Nrf2 target genes encode antioxidant enzymes, and proteins involved in xenobiotic detoxification, repair and removal of damaged proteins and organ...

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Autores principales: Dinkova‐Kostova, Albena T., Kostov, Rumen V., Kazantsev, Aleksey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221096/
https://www.ncbi.nlm.nih.gov/pubmed/29323772
http://dx.doi.org/10.1111/febs.14379
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author Dinkova‐Kostova, Albena T.
Kostov, Rumen V.
Kazantsev, Aleksey G.
author_facet Dinkova‐Kostova, Albena T.
Kostov, Rumen V.
Kazantsev, Aleksey G.
author_sort Dinkova‐Kostova, Albena T.
collection PubMed
description The transcription factor Nrf2 (nuclear factor‐erythroid 2 p45‐related factor 2) functions at the interface of cellular redox and intermediary metabolism. Nrf2 target genes encode antioxidant enzymes, and proteins involved in xenobiotic detoxification, repair and removal of damaged proteins and organelles, inflammation, and mitochondrial bioenergetics. The function of Nrf2 is altered in many neurodegenerative disorders, such as Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and Friedreich's ataxia. Nrf2 activation mitigates multiple pathogenic processes involved in these neurodegenerative disorders through upregulation of antioxidant defenses, inhibition of inflammation, improvement of mitochondrial function, and maintenance of protein homeostasis. Small molecule pharmacological activators of Nrf2 have shown protective effects in numerous animal models of neurodegenerative diseases, and in cultures of human cells expressing mutant proteins. Targeting Nrf2 signaling may provide a therapeutic option to delay onset, slow progression, and ameliorate symptoms of neurodegenerative disorders.
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spelling pubmed-62210962018-11-15 The role of Nrf2 signaling in counteracting neurodegenerative diseases Dinkova‐Kostova, Albena T. Kostov, Rumen V. Kazantsev, Aleksey G. FEBS J Review Articles The transcription factor Nrf2 (nuclear factor‐erythroid 2 p45‐related factor 2) functions at the interface of cellular redox and intermediary metabolism. Nrf2 target genes encode antioxidant enzymes, and proteins involved in xenobiotic detoxification, repair and removal of damaged proteins and organelles, inflammation, and mitochondrial bioenergetics. The function of Nrf2 is altered in many neurodegenerative disorders, such as Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and Friedreich's ataxia. Nrf2 activation mitigates multiple pathogenic processes involved in these neurodegenerative disorders through upregulation of antioxidant defenses, inhibition of inflammation, improvement of mitochondrial function, and maintenance of protein homeostasis. Small molecule pharmacological activators of Nrf2 have shown protective effects in numerous animal models of neurodegenerative diseases, and in cultures of human cells expressing mutant proteins. Targeting Nrf2 signaling may provide a therapeutic option to delay onset, slow progression, and ameliorate symptoms of neurodegenerative disorders. John Wiley and Sons Inc. 2018-01-29 2018-10 /pmc/articles/PMC6221096/ /pubmed/29323772 http://dx.doi.org/10.1111/febs.14379 Text en © 2018 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Dinkova‐Kostova, Albena T.
Kostov, Rumen V.
Kazantsev, Aleksey G.
The role of Nrf2 signaling in counteracting neurodegenerative diseases
title The role of Nrf2 signaling in counteracting neurodegenerative diseases
title_full The role of Nrf2 signaling in counteracting neurodegenerative diseases
title_fullStr The role of Nrf2 signaling in counteracting neurodegenerative diseases
title_full_unstemmed The role of Nrf2 signaling in counteracting neurodegenerative diseases
title_short The role of Nrf2 signaling in counteracting neurodegenerative diseases
title_sort role of nrf2 signaling in counteracting neurodegenerative diseases
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221096/
https://www.ncbi.nlm.nih.gov/pubmed/29323772
http://dx.doi.org/10.1111/febs.14379
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