Short Total Synthesis of Ajoene

We describe a short total synthesis of ajoene, a major biologically active constituent of garlic. The instability of allicin as the only other known alternative starting material has led to the development of a reliable procedure for the synthesis of ajoene from simple building blocks that is also s...

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Detalles Bibliográficos
Autores principales: Silva, Filipa, Khokhar, Shaista S., Williams, Danielle M., Saunders, Robert, Evans, Gareth J. S., Graz, Michael, Wirth, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221122/
https://www.ncbi.nlm.nih.gov/pubmed/30079981
http://dx.doi.org/10.1002/anie.201808605
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author Silva, Filipa
Khokhar, Shaista S.
Williams, Danielle M.
Saunders, Robert
Evans, Gareth J. S.
Graz, Michael
Wirth, Thomas
author_facet Silva, Filipa
Khokhar, Shaista S.
Williams, Danielle M.
Saunders, Robert
Evans, Gareth J. S.
Graz, Michael
Wirth, Thomas
author_sort Silva, Filipa
collection PubMed
description We describe a short total synthesis of ajoene, a major biologically active constituent of garlic. The instability of allicin as the only other known alternative starting material has led to the development of a reliable procedure for the synthesis of ajoene from simple building blocks that is also suitable for upscale operations.
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spelling pubmed-62211222018-11-15 Short Total Synthesis of Ajoene Silva, Filipa Khokhar, Shaista S. Williams, Danielle M. Saunders, Robert Evans, Gareth J. S. Graz, Michael Wirth, Thomas Angew Chem Int Ed Engl Communications We describe a short total synthesis of ajoene, a major biologically active constituent of garlic. The instability of allicin as the only other known alternative starting material has led to the development of a reliable procedure for the synthesis of ajoene from simple building blocks that is also suitable for upscale operations. John Wiley and Sons Inc. 2018-08-19 2018-09-17 /pmc/articles/PMC6221122/ /pubmed/30079981 http://dx.doi.org/10.1002/anie.201808605 Text en © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Silva, Filipa
Khokhar, Shaista S.
Williams, Danielle M.
Saunders, Robert
Evans, Gareth J. S.
Graz, Michael
Wirth, Thomas
Short Total Synthesis of Ajoene
title Short Total Synthesis of Ajoene
title_full Short Total Synthesis of Ajoene
title_fullStr Short Total Synthesis of Ajoene
title_full_unstemmed Short Total Synthesis of Ajoene
title_short Short Total Synthesis of Ajoene
title_sort short total synthesis of ajoene
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221122/
https://www.ncbi.nlm.nih.gov/pubmed/30079981
http://dx.doi.org/10.1002/anie.201808605
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AT saundersrobert shorttotalsynthesisofajoene
AT evansgarethjs shorttotalsynthesisofajoene
AT grazmichael shorttotalsynthesisofajoene
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