Cargando…

Safety, immunogenicity, pharmacokinetics, and efficacy of degradation of anti‐HLA antibodies by IdeS (imlifidase) in chronic kidney disease patients

Safety, immunogenicity, pharmacokinetics, and efficacy of the IgG‐degrading enzyme of Streptococcus pyogenes (IdeS [imlifidase]) were assessed in a single‐center, open‐label ascending‐dose study in highly sensitized patients with chronic kidney disease. Eight patients with cytotoxic PRAs (median cyt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lorant, Tomas, Bengtsson, Mats, Eich, Torsten, Eriksson, Britt‐Marie, Winstedt, Lena, Järnum, Sofia, Stenberg, Yvonne, Robertson, Anna‐Karin, Mosén, Kristina, Björck, Lars, Bäckman, Lars, Larsson, Erik, Wood, Kathryn, Tufveson, Gunnar, Kjellman, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	ORIGINAL ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221156/ https://www.ncbi.nlm.nih.gov/pubmed/29561066 http://dx.doi.org/10.1111/ajt.14733

Ejemplares similares

Imlifidase-generated Single-cleaved IgG: Implications for Transplantation
por: Bockermann, Robert, et al.
Publicado: (2021)

Streptococcus pyogenes Infection and the Human Proteome with a Special Focus on the Immunoglobulin G-cleaving Enzyme IdeS
por: Karlsson, Christofer A. Q., et al.
Publicado: (2018)

Imlifidase for the treatment of anti‐HLA antibody‐mediated processes in kidney transplantation
por: Huang, Edmund, et al.
Publicado: (2021)

Imlifidase Desensitization in Crossmatch-positive, Highly Sensitized Kidney Transplant Recipients: Results of an International Phase 2 Trial (Highdes)
por: Jordan, Stanley C., et al.
Publicado: (2021)

Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS – A Novel Therapeutic Opportunity
por: Winstedt, Lena, et al.
Publicado: (2015)

Prime Time for HLA Desensitization: Imlifidase in the Spotlight
por: Bestard, Oriol, et al.
Publicado: (2023)

Outcomes at 3 years posttransplant in imlifidase‐desensitized kidney transplant patients
por: Kjellman, Christian, et al.
Publicado: (2021)

Desensitization using imlifidase and EndoS enables chimerism induction in allosensitized recipient mice
por: Lin, Jiaxin, et al.
Publicado: (2020)

Donor-derived urologic cancers after renal transplantation: A retrospective non-randomized scientific analysis
por: Hellström, Vivan, et al.
Publicado: (2022)

IdeS: A Bacterial Proteolytic Enzyme with Therapeutic Potential
por: Johansson, Björn P., et al.
Publicado: (2008)

Imlifidase for Kidney Transplantation of Highly Sensitized Patients With a Positive Crossmatch: The French Consensus Guidelines
por: Couzi, Lionel, et al.
Publicado: (2023)

IdeS, a secreted proteinase of Streptococcus pyogenes, is bound to a nuclease at the bacterial surface where it inactivates opsonizing IgG antibodies
por: Frick, Inga-Maria, et al.
Publicado: (2023)

The IgG-degrading enzyme, Imlifidase, restores the therapeutic activity of FVIII in inhibitor-positive hemophilia A mice.
por: Bou-Jaoudeh, Melissa, et al.
Publicado: (2023)

Association of Protective HLA-A With HLA-B(∗)27 Positive Ankylosing Spondylitis
por: Nordin, Jessika, et al.
Publicado: (2021)

A Comparison of HLA Molecular Mismatch Methods to Determine HLA Immunogenicity
por: Wiebe, Chris, et al.
Publicado: (2018)

IDE : inventario de dependencia emocional /
por: Aiquipa Tello, Jesús Joel
Publicado: (2015)

Une lumineuse idée
Publicado: (2004)

Disque PC IDE
Publicado: (1995)

Lessons learned from IDeAl — 33 recommendations from the IDeAl-net about design and analysis of small population clinical trials
por: Hilgers, Ralf-Dieter, et al.
Publicado: (2018)

Thésaurus Larousse: des idées aux mots, des mots aux idées
por: Péchoin, Daniel
Publicado: (1992)

Audio-video recording during laparoscopic surgery reduces irrelevant conversation between surgeons: a cohort study
por: Bergström, Hannah, et al.
Publicado: (2018)

Identification of HLA-DRB1 association to adalimumab immunogenicity
por: Liu, Mohan, et al.
Publicado: (2018)

Predicting HLA CD4 Immunogenicity in Human Populations
por: Dhanda, Sandeep Kumar, et al.
Publicado: (2018)

Visión fiscal : (IETU-IDE) /
por: Calvo Langarica, César
Publicado: (2008)

CERN, des idées étonnantes
por: Gourber, J P
Publicado: (1982)

Eclipse IDE: pocket guide
por: Burnette, Ed
Publicado: (2005)

Kühne idee einer parallelwelt
por: Imhasly, Patrick
Publicado: (2006)

Zur idee der Transzendentalphilosophie
por: Lauth, Reinhard
Publicado: (1965)

Getting started with the Lazarus IDE
por: Person, Roderick
Publicado: (2013)

The effect of hemorrhagic shock and intraosseous adrenaline injection on the delivery of a subsequently administered drug - an experimental study
por: Eriksson, Mats, et al.
Publicado: (2019)

Effects of extensive bleeding in pigs on laboratory biomarkers
por: Larsson, Anders, et al.
Publicado: (2021)

Self-reported leisure time physical activity: a useful assessment tool in everyday health care
por: Rödjer, Lars, et al.
Publicado: (2012)

Comparing ambient, air-convection, and fluid-convection heating techniques in treating hypothermic burn patients, a clinical RCT
por: Kjellman, Britt-Marie, et al.
Publicado: (2011)

In silico characterization of immunogenic epitopes presented by HLA-Cw*0401
por: Tong, Joo Chuan, et al.
Publicado: (2007)

Humoral Alloimmunity in Transplantation: Relevance of HLA Epitope Antigenicity and Immunogenicity
por: Duquesnoy, René J.
Publicado: (2011)

Diagnostic validity of the MINI-KID disorder classifications in specialized child and adolescent psychiatric outpatient clinics in Sweden
por: Högberg, Camilla, et al.
Publicado: (2019)

Calcium: A Crucial Potentiator for Efficient Enzyme Digestion of the Human Pancreas
por: Eich, Torsten, et al.
Publicado: (2018)

Nouvelles idées pour les accélérateurs
Publicado: (1985)

Europa als Idee und Wirklichkeit /
Publicado: (1955)

Les idées de mademoiselle Marianne
Publicado: (1884)

Cannot write session to /tmp/vufind_sessions/sess_96huglrlikmqossrk3dl43dc80