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RNA methylation in nuclear pre‐mRNA processing
Eukaryotic RNA can carry more than 100 different types of chemical modifications. Early studies have been focused on modifications of highly abundant RNA, such as ribosomal RNA and transfer RNA, but recent technical advances have made it possible to also study messenger RNA (mRNA). Subsequently, mRN...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221173/ https://www.ncbi.nlm.nih.gov/pubmed/29921017 http://dx.doi.org/10.1002/wrna.1489 |
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author | Covelo‐Molares, Helena Bartosovic, Marek Vanacova, Stepanka |
author_facet | Covelo‐Molares, Helena Bartosovic, Marek Vanacova, Stepanka |
author_sort | Covelo‐Molares, Helena |
collection | PubMed |
description | Eukaryotic RNA can carry more than 100 different types of chemical modifications. Early studies have been focused on modifications of highly abundant RNA, such as ribosomal RNA and transfer RNA, but recent technical advances have made it possible to also study messenger RNA (mRNA). Subsequently, mRNA modifications, namely methylation, have emerged as key players in eukaryotic gene expression regulation. The most abundant and widely studied internal mRNA modification is N(6)‐methyladenosine (m(6)A), but the list of mRNA chemical modifications continues to grow as fast as interest in this field. Over the past decade, transcriptome‐wide studies combined with advanced biochemistry and the discovery of methylation writers, readers, and erasers revealed roles for mRNA methylation in the regulation of nearly every aspect of the mRNA life cycle and in diverse cellular, developmental, and disease processes. Although large parts of mRNA function are linked to its cytoplasmic stability and regulation of its translation, a number of studies have begun to provide evidence for methylation‐regulated nuclear processes. In this review, we summarize the recent advances in RNA methylation research and highlight how these new findings have contributed to our understanding of methylation‐dependent RNA processing in the nucleus. RNA Processing > RNA Editing and Modification. RNA Processing > Splicing Regulation/Alternative Splicing. RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications. |
format | Online Article Text |
id | pubmed-6221173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62211732018-11-15 RNA methylation in nuclear pre‐mRNA processing Covelo‐Molares, Helena Bartosovic, Marek Vanacova, Stepanka Wiley Interdiscip Rev RNA Advanced Reviews Eukaryotic RNA can carry more than 100 different types of chemical modifications. Early studies have been focused on modifications of highly abundant RNA, such as ribosomal RNA and transfer RNA, but recent technical advances have made it possible to also study messenger RNA (mRNA). Subsequently, mRNA modifications, namely methylation, have emerged as key players in eukaryotic gene expression regulation. The most abundant and widely studied internal mRNA modification is N(6)‐methyladenosine (m(6)A), but the list of mRNA chemical modifications continues to grow as fast as interest in this field. Over the past decade, transcriptome‐wide studies combined with advanced biochemistry and the discovery of methylation writers, readers, and erasers revealed roles for mRNA methylation in the regulation of nearly every aspect of the mRNA life cycle and in diverse cellular, developmental, and disease processes. Although large parts of mRNA function are linked to its cytoplasmic stability and regulation of its translation, a number of studies have begun to provide evidence for methylation‐regulated nuclear processes. In this review, we summarize the recent advances in RNA methylation research and highlight how these new findings have contributed to our understanding of methylation‐dependent RNA processing in the nucleus. RNA Processing > RNA Editing and Modification. RNA Processing > Splicing Regulation/Alternative Splicing. RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications. John Wiley & Sons, Inc. 2018-06-19 2018 /pmc/articles/PMC6221173/ /pubmed/29921017 http://dx.doi.org/10.1002/wrna.1489 Text en © 2018 The Authors. WIREs RNA published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Advanced Reviews Covelo‐Molares, Helena Bartosovic, Marek Vanacova, Stepanka RNA methylation in nuclear pre‐mRNA processing |
title | RNA methylation in nuclear pre‐mRNA processing |
title_full | RNA methylation in nuclear pre‐mRNA processing |
title_fullStr | RNA methylation in nuclear pre‐mRNA processing |
title_full_unstemmed | RNA methylation in nuclear pre‐mRNA processing |
title_short | RNA methylation in nuclear pre‐mRNA processing |
title_sort | rna methylation in nuclear pre‐mrna processing |
topic | Advanced Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221173/ https://www.ncbi.nlm.nih.gov/pubmed/29921017 http://dx.doi.org/10.1002/wrna.1489 |
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