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Modeling household transmission dynamics: Application to waterborne diarrheal disease in Central Africa
INTRODUCTION: We describe a method for analyzing the within-household network dynamics of a disease transmission. We apply it to analyze the occurrences of endemic diarrheal disease in Cameroon, Central Africa based on observational, cross-sectional data available from household health surveys. METH...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221320/ https://www.ncbi.nlm.nih.gov/pubmed/30403729 http://dx.doi.org/10.1371/journal.pone.0206418 |
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author | Woroszyło, Casper Choi, Boseung Healy Profitós, Jessica Lee, Jiyoung Garabed, Rebecca Rempala, Grzegorz A. |
author_facet | Woroszyło, Casper Choi, Boseung Healy Profitós, Jessica Lee, Jiyoung Garabed, Rebecca Rempala, Grzegorz A. |
author_sort | Woroszyło, Casper |
collection | PubMed |
description | INTRODUCTION: We describe a method for analyzing the within-household network dynamics of a disease transmission. We apply it to analyze the occurrences of endemic diarrheal disease in Cameroon, Central Africa based on observational, cross-sectional data available from household health surveys. METHODS: To analyze the data, we apply formalism of the dynamic SID (susceptible-infected-diseased) process that describes the disease steady-state while adjusting for the household age-structure and environment contamination, such as water contamination. The SID transmission rates are estimated via MCMC method with the help of the so-called synthetic likelihood approach. RESULTS: The SID model is fitted to a dataset on diarrhea occurrence from 63 households in Cameroon. We show that the model allows for quantification of the effects of drinking water contamination on both transmission and recovery rates for household diarrheal disease occurrence as well as for estimation of the rate of silent (unobserved) infections. CONCLUSIONS: The new estimation method appears capable of genuinely capturing the complex dynamics of disease transmission across various human, animal and environmental compartments at the household level. Our approach is quite general and can be used in other epidemiological settings where it is desirable to fit transmission rates using cross-sectional data. SOFTWARE SHARING: The R-scripts for carrying out the computational analysis described in the paper are available at https://github.com/cbskust/SID. |
format | Online Article Text |
id | pubmed-6221320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-62213202018-11-19 Modeling household transmission dynamics: Application to waterborne diarrheal disease in Central Africa Woroszyło, Casper Choi, Boseung Healy Profitós, Jessica Lee, Jiyoung Garabed, Rebecca Rempala, Grzegorz A. PLoS One Research Article INTRODUCTION: We describe a method for analyzing the within-household network dynamics of a disease transmission. We apply it to analyze the occurrences of endemic diarrheal disease in Cameroon, Central Africa based on observational, cross-sectional data available from household health surveys. METHODS: To analyze the data, we apply formalism of the dynamic SID (susceptible-infected-diseased) process that describes the disease steady-state while adjusting for the household age-structure and environment contamination, such as water contamination. The SID transmission rates are estimated via MCMC method with the help of the so-called synthetic likelihood approach. RESULTS: The SID model is fitted to a dataset on diarrhea occurrence from 63 households in Cameroon. We show that the model allows for quantification of the effects of drinking water contamination on both transmission and recovery rates for household diarrheal disease occurrence as well as for estimation of the rate of silent (unobserved) infections. CONCLUSIONS: The new estimation method appears capable of genuinely capturing the complex dynamics of disease transmission across various human, animal and environmental compartments at the household level. Our approach is quite general and can be used in other epidemiological settings where it is desirable to fit transmission rates using cross-sectional data. SOFTWARE SHARING: The R-scripts for carrying out the computational analysis described in the paper are available at https://github.com/cbskust/SID. Public Library of Science 2018-11-07 /pmc/articles/PMC6221320/ /pubmed/30403729 http://dx.doi.org/10.1371/journal.pone.0206418 Text en © 2018 Woroszyło et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Woroszyło, Casper Choi, Boseung Healy Profitós, Jessica Lee, Jiyoung Garabed, Rebecca Rempala, Grzegorz A. Modeling household transmission dynamics: Application to waterborne diarrheal disease in Central Africa |
title | Modeling household transmission dynamics: Application to waterborne diarrheal disease in Central Africa |
title_full | Modeling household transmission dynamics: Application to waterborne diarrheal disease in Central Africa |
title_fullStr | Modeling household transmission dynamics: Application to waterborne diarrheal disease in Central Africa |
title_full_unstemmed | Modeling household transmission dynamics: Application to waterborne diarrheal disease in Central Africa |
title_short | Modeling household transmission dynamics: Application to waterborne diarrheal disease in Central Africa |
title_sort | modeling household transmission dynamics: application to waterborne diarrheal disease in central africa |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221320/ https://www.ncbi.nlm.nih.gov/pubmed/30403729 http://dx.doi.org/10.1371/journal.pone.0206418 |
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