Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism

BACKGROUND: The possibility of emergence of praziquantel-resistant Schistosoma parasites and the lack of other effective drugs demand the discovery of new schistosomicidal agents. In this context the study of compounds that target histone-modifying enzymes is extremely promising. Our aim was to inve...

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Detalles Bibliográficos
Autores principales: Pereira, Adriana S. A., Amaral, Murilo S., Vasconcelos, Elton J. R., Pires, David S., Asif, Huma, daSilva, Lucas F., Morales-Vicente, David A., Carneiro, Vitor C., Angeli, Claudia B., Palmisano, Giuseppe, Fantappie, Marcelo R., Pierce, Raymond J., Setubal, João C., Verjovski-Almeida, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221359/
https://www.ncbi.nlm.nih.gov/pubmed/30365505
http://dx.doi.org/10.1371/journal.pntd.0006873

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