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A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei

Polyamines are essential for cell growth of eukaryotes including the etiologic agent of human African trypanosomiasis (HAT), Trypanosoma brucei. In trypanosomatids, a key enzyme in the polyamine biosynthetic pathway, S-adenosylmethionine decarboxylase (TbAdoMetDC) heterodimerizes with a unique catal...

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Detalles Bibliográficos
Autores principales:	Patel, Manish M., Volkov, Oleg A., Leija, Christopher, Lemoff, Andrew, Phillips, Margaret A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221367/ https://www.ncbi.nlm.nih.gov/pubmed/30365568 http://dx.doi.org/10.1371/journal.ppat.1007404

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