Phase I clinical trial of an intranodally administered mRNA-based therapeutic vaccine against HIV-1 infection

OBJECTIVE: The efficacy of therapeutic vaccines against HIV-1 infection has been modest. New inerts to redirect responses to vulnerable sites are urgently needed to improve these results. DESIGN: We performed the first-in-human clinical trial with naked mRNA (iHIVARNA) combining a dendritic cell act...

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Detalles Bibliográficos
Autores principales: Leal, Lorna, Guardo, Alberto C., Morón-López, Sara, Salgado, Maria, Mothe, Beatriz, Heirman, Carlo, Pannus, Pieter, Vanham, Guido, van den Ham, Henk Jan, Gruters, Rob, Andeweg, Arno, Van Meirvenne, Sonja, Pich, Judit, Arnaiz, Joan Albert, Gatell, Josep M., Brander, Christian, Thielemans, Kris, Martínez-Picado, Javier, Plana, Montserrat, García, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Clinical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221380/
https://www.ncbi.nlm.nih.gov/pubmed/30289805
http://dx.doi.org/10.1097/QAD.0000000000002026

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