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Engineering human megakaryocytic microparticles for targeted delivery of nucleic acids to hematopoietic stem and progenitor cells

Hematopoietic stem and progenitor cells (HSPCs) are important target cells for gene therapy applications. Current genetic modifications of HSPCs rely on viral vectors in vivo or electroporation ex vivo. Here, we developed a nonviral system based on megakaryocytic microparticles (MPs) for targeted de...

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Detalles Bibliográficos
Autores principales:	Kao, Chen-Yuan, Papoutsakis, Eleftherios T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221511/ https://www.ncbi.nlm.nih.gov/pubmed/30417099 http://dx.doi.org/10.1126/sciadv.aau6762

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