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Autoimmune Thyroiditis with Hypothyroidism Induced by Sugar Substitutes

The use of sugar substitutes (artificial sweeteners or non-nutritive sweeteners) has increased dramatically in the past few decades. They have been used as a substitute for sucrose (table sugar) in various diet-related disorders. Their excessive use has been linked to hyperphagia and obesity-related...

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Autores principales: Sachmechi, Issac, Khalid, Amna, Awan, Saba Iqbal, Malik, Zohra R, Sharifzadeh, Mohaddeseh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221534/
https://www.ncbi.nlm.nih.gov/pubmed/30430057
http://dx.doi.org/10.7759/cureus.3268
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author Sachmechi, Issac
Khalid, Amna
Awan, Saba Iqbal
Malik, Zohra R
Sharifzadeh, Mohaddeseh
author_facet Sachmechi, Issac
Khalid, Amna
Awan, Saba Iqbal
Malik, Zohra R
Sharifzadeh, Mohaddeseh
author_sort Sachmechi, Issac
collection PubMed
description The use of sugar substitutes (artificial sweeteners or non-nutritive sweeteners) has increased dramatically in the past few decades. They have been used as a substitute for sucrose (table sugar) in various diet-related disorders. Their excessive use has been linked to hyperphagia and obesity-related disorders. Hashimoto’s thyroiditis (chronic autoimmune thyroiditis) is a disease that involves the immune-mediated destruction of the thyroid gland, gradually leading to its failure. Animal studies report that artificial sweeteners affect the immune system. Moreover, animal studies show that sucralose diminishes the thyroid axis activity. We are presenting the case of a 52-year-old female with autoimmune thyroiditis with hypothyroidism (Hashimoto’s thyroiditis) induced by an excessive intake of beverages containing non-nutritive sweeteners. She was ruled out for any other autoimmune disorder. The association between Hashimoto’s thyroiditis and the excessive consumption of sugar substitutes is shown by the quick return of thyroid stimulating hormone and antibody levels to normal after eliminating the use of sugar substitutes. Thus, it suggests that the sugar substitutes were the culprit in the development of Hashimoto’s thyroiditis in our patient.
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spelling pubmed-62215342018-11-14 Autoimmune Thyroiditis with Hypothyroidism Induced by Sugar Substitutes Sachmechi, Issac Khalid, Amna Awan, Saba Iqbal Malik, Zohra R Sharifzadeh, Mohaddeseh Cureus Endocrinology/Diabetes/Metabolism The use of sugar substitutes (artificial sweeteners or non-nutritive sweeteners) has increased dramatically in the past few decades. They have been used as a substitute for sucrose (table sugar) in various diet-related disorders. Their excessive use has been linked to hyperphagia and obesity-related disorders. Hashimoto’s thyroiditis (chronic autoimmune thyroiditis) is a disease that involves the immune-mediated destruction of the thyroid gland, gradually leading to its failure. Animal studies report that artificial sweeteners affect the immune system. Moreover, animal studies show that sucralose diminishes the thyroid axis activity. We are presenting the case of a 52-year-old female with autoimmune thyroiditis with hypothyroidism (Hashimoto’s thyroiditis) induced by an excessive intake of beverages containing non-nutritive sweeteners. She was ruled out for any other autoimmune disorder. The association between Hashimoto’s thyroiditis and the excessive consumption of sugar substitutes is shown by the quick return of thyroid stimulating hormone and antibody levels to normal after eliminating the use of sugar substitutes. Thus, it suggests that the sugar substitutes were the culprit in the development of Hashimoto’s thyroiditis in our patient. Cureus 2018-09-07 /pmc/articles/PMC6221534/ /pubmed/30430057 http://dx.doi.org/10.7759/cureus.3268 Text en Copyright © 2018, Sachmechi et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Sachmechi, Issac
Khalid, Amna
Awan, Saba Iqbal
Malik, Zohra R
Sharifzadeh, Mohaddeseh
Autoimmune Thyroiditis with Hypothyroidism Induced by Sugar Substitutes
title Autoimmune Thyroiditis with Hypothyroidism Induced by Sugar Substitutes
title_full Autoimmune Thyroiditis with Hypothyroidism Induced by Sugar Substitutes
title_fullStr Autoimmune Thyroiditis with Hypothyroidism Induced by Sugar Substitutes
title_full_unstemmed Autoimmune Thyroiditis with Hypothyroidism Induced by Sugar Substitutes
title_short Autoimmune Thyroiditis with Hypothyroidism Induced by Sugar Substitutes
title_sort autoimmune thyroiditis with hypothyroidism induced by sugar substitutes
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221534/
https://www.ncbi.nlm.nih.gov/pubmed/30430057
http://dx.doi.org/10.7759/cureus.3268
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