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TET2 coactivates gene expression through demethylation of enhancers

The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is frequently mutated or dysregulated in multiple human cancers, and loss of TET2 is associated with changes in DNA methylation patterns. Here, using...

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Detalles Bibliográficos
Autores principales:	Wang, Lu, Ozark, Patrick A., Smith, Edwin R., Zhao, Zibo, Marshall, Stacy A., Rendleman, Emily J., Piunti, Andrea, Ryan, Caila, Whelan, Anna L., Helmin, Kathryn A., Morgan, Marc Alard, Zou, Lihua, Singer, Benjamin D., Shilatifard, Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221537/ https://www.ncbi.nlm.nih.gov/pubmed/30417100 http://dx.doi.org/10.1126/sciadv.aau6986

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