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Light-dependent pathways for dopaminergic amacrine cell development and function
Retinal dopamine is a critical modulator of high acuity, light-adapted vision and photoreceptor coupling in the retina. Dopaminergic amacrine cells (DACs) serve as the sole source of retinal dopamine, and dopamine release in the retina follows a circadian rhythm and is modulated by light exposure. H...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221543/ https://www.ncbi.nlm.nih.gov/pubmed/30403373 http://dx.doi.org/10.7554/eLife.39866 |
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author | Munteanu, Teona Noronha, Katelyn J Leung, Amanda C Pan, Simon Lucas, Jasmine A Schmidt, Tiffany M |
author_facet | Munteanu, Teona Noronha, Katelyn J Leung, Amanda C Pan, Simon Lucas, Jasmine A Schmidt, Tiffany M |
author_sort | Munteanu, Teona |
collection | PubMed |
description | Retinal dopamine is a critical modulator of high acuity, light-adapted vision and photoreceptor coupling in the retina. Dopaminergic amacrine cells (DACs) serve as the sole source of retinal dopamine, and dopamine release in the retina follows a circadian rhythm and is modulated by light exposure. However, the retinal circuits through which light influences the development and function of DACs are still unknown. Intrinsically photosensitive retinal ganglion cells (ipRGCs) have emerged as a prime target for influencing retinal dopamine levels because they costratify with DACs in the inner plexiform layer and signal to them in a retrograde manner. Surprisingly, using genetic mouse models lacking specific phototransduction pathways, we find that while light influences the total number of DACs and retinal dopamine levels, this effect does not require ipRGCs. Instead, we find that the rod pathway is a critical modulator of both DAC number and retinal dopamine levels. |
format | Online Article Text |
id | pubmed-6221543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-62215432018-11-11 Light-dependent pathways for dopaminergic amacrine cell development and function Munteanu, Teona Noronha, Katelyn J Leung, Amanda C Pan, Simon Lucas, Jasmine A Schmidt, Tiffany M eLife Neuroscience Retinal dopamine is a critical modulator of high acuity, light-adapted vision and photoreceptor coupling in the retina. Dopaminergic amacrine cells (DACs) serve as the sole source of retinal dopamine, and dopamine release in the retina follows a circadian rhythm and is modulated by light exposure. However, the retinal circuits through which light influences the development and function of DACs are still unknown. Intrinsically photosensitive retinal ganglion cells (ipRGCs) have emerged as a prime target for influencing retinal dopamine levels because they costratify with DACs in the inner plexiform layer and signal to them in a retrograde manner. Surprisingly, using genetic mouse models lacking specific phototransduction pathways, we find that while light influences the total number of DACs and retinal dopamine levels, this effect does not require ipRGCs. Instead, we find that the rod pathway is a critical modulator of both DAC number and retinal dopamine levels. eLife Sciences Publications, Ltd 2018-11-07 /pmc/articles/PMC6221543/ /pubmed/30403373 http://dx.doi.org/10.7554/eLife.39866 Text en © 2018, Munteanu et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Munteanu, Teona Noronha, Katelyn J Leung, Amanda C Pan, Simon Lucas, Jasmine A Schmidt, Tiffany M Light-dependent pathways for dopaminergic amacrine cell development and function |
title | Light-dependent pathways for dopaminergic amacrine cell development and function |
title_full | Light-dependent pathways for dopaminergic amacrine cell development and function |
title_fullStr | Light-dependent pathways for dopaminergic amacrine cell development and function |
title_full_unstemmed | Light-dependent pathways for dopaminergic amacrine cell development and function |
title_short | Light-dependent pathways for dopaminergic amacrine cell development and function |
title_sort | light-dependent pathways for dopaminergic amacrine cell development and function |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221543/ https://www.ncbi.nlm.nih.gov/pubmed/30403373 http://dx.doi.org/10.7554/eLife.39866 |
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