Cargando…

Light-dependent pathways for dopaminergic amacrine cell development and function

Retinal dopamine is a critical modulator of high acuity, light-adapted vision and photoreceptor coupling in the retina. Dopaminergic amacrine cells (DACs) serve as the sole source of retinal dopamine, and dopamine release in the retina follows a circadian rhythm and is modulated by light exposure. H...

Descripción completa

Detalles Bibliográficos
Autores principales: Munteanu, Teona, Noronha, Katelyn J, Leung, Amanda C, Pan, Simon, Lucas, Jasmine A, Schmidt, Tiffany M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221543/
https://www.ncbi.nlm.nih.gov/pubmed/30403373
http://dx.doi.org/10.7554/eLife.39866
_version_ 1783369038067400704
author Munteanu, Teona
Noronha, Katelyn J
Leung, Amanda C
Pan, Simon
Lucas, Jasmine A
Schmidt, Tiffany M
author_facet Munteanu, Teona
Noronha, Katelyn J
Leung, Amanda C
Pan, Simon
Lucas, Jasmine A
Schmidt, Tiffany M
author_sort Munteanu, Teona
collection PubMed
description Retinal dopamine is a critical modulator of high acuity, light-adapted vision and photoreceptor coupling in the retina. Dopaminergic amacrine cells (DACs) serve as the sole source of retinal dopamine, and dopamine release in the retina follows a circadian rhythm and is modulated by light exposure. However, the retinal circuits through which light influences the development and function of DACs are still unknown. Intrinsically photosensitive retinal ganglion cells (ipRGCs) have emerged as a prime target for influencing retinal dopamine levels because they costratify with DACs in the inner plexiform layer and signal to them in a retrograde manner. Surprisingly, using genetic mouse models lacking specific phototransduction pathways, we find that while light influences the total number of DACs and retinal dopamine levels, this effect does not require ipRGCs. Instead, we find that the rod pathway is a critical modulator of both DAC number and retinal dopamine levels.
format Online
Article
Text
id pubmed-6221543
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-62215432018-11-11 Light-dependent pathways for dopaminergic amacrine cell development and function Munteanu, Teona Noronha, Katelyn J Leung, Amanda C Pan, Simon Lucas, Jasmine A Schmidt, Tiffany M eLife Neuroscience Retinal dopamine is a critical modulator of high acuity, light-adapted vision and photoreceptor coupling in the retina. Dopaminergic amacrine cells (DACs) serve as the sole source of retinal dopamine, and dopamine release in the retina follows a circadian rhythm and is modulated by light exposure. However, the retinal circuits through which light influences the development and function of DACs are still unknown. Intrinsically photosensitive retinal ganglion cells (ipRGCs) have emerged as a prime target for influencing retinal dopamine levels because they costratify with DACs in the inner plexiform layer and signal to them in a retrograde manner. Surprisingly, using genetic mouse models lacking specific phototransduction pathways, we find that while light influences the total number of DACs and retinal dopamine levels, this effect does not require ipRGCs. Instead, we find that the rod pathway is a critical modulator of both DAC number and retinal dopamine levels. eLife Sciences Publications, Ltd 2018-11-07 /pmc/articles/PMC6221543/ /pubmed/30403373 http://dx.doi.org/10.7554/eLife.39866 Text en © 2018, Munteanu et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Munteanu, Teona
Noronha, Katelyn J
Leung, Amanda C
Pan, Simon
Lucas, Jasmine A
Schmidt, Tiffany M
Light-dependent pathways for dopaminergic amacrine cell development and function
title Light-dependent pathways for dopaminergic amacrine cell development and function
title_full Light-dependent pathways for dopaminergic amacrine cell development and function
title_fullStr Light-dependent pathways for dopaminergic amacrine cell development and function
title_full_unstemmed Light-dependent pathways for dopaminergic amacrine cell development and function
title_short Light-dependent pathways for dopaminergic amacrine cell development and function
title_sort light-dependent pathways for dopaminergic amacrine cell development and function
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221543/
https://www.ncbi.nlm.nih.gov/pubmed/30403373
http://dx.doi.org/10.7554/eLife.39866
work_keys_str_mv AT munteanuteona lightdependentpathwaysfordopaminergicamacrinecelldevelopmentandfunction
AT noronhakatelynj lightdependentpathwaysfordopaminergicamacrinecelldevelopmentandfunction
AT leungamandac lightdependentpathwaysfordopaminergicamacrinecelldevelopmentandfunction
AT pansimon lightdependentpathwaysfordopaminergicamacrinecelldevelopmentandfunction
AT lucasjasminea lightdependentpathwaysfordopaminergicamacrinecelldevelopmentandfunction
AT schmidttiffanym lightdependentpathwaysfordopaminergicamacrinecelldevelopmentandfunction