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Prognostic value of osteopontin in patients with hepatocellular carcinoma: A systematic review and meta-analysis
PURPOSE: The prognostic value of tissue and serum osteopontin (OPN) in hepatocellular carcinoma (HCC) remain controversial. The aim of present meta-analysis was to evaluate the prognostic value of OPN in patients with HCC. METHODS: Eligible studies were systematically searched by PubMed, EMBASE, and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221565/ https://www.ncbi.nlm.nih.gov/pubmed/30412113 http://dx.doi.org/10.1097/MD.0000000000012954 |
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author | Sun, Tingting Li, Peng Sun, Diwen Bu, Qingao Li, Guoqiang |
author_facet | Sun, Tingting Li, Peng Sun, Diwen Bu, Qingao Li, Guoqiang |
author_sort | Sun, Tingting |
collection | PubMed |
description | PURPOSE: The prognostic value of tissue and serum osteopontin (OPN) in hepatocellular carcinoma (HCC) remain controversial. The aim of present meta-analysis was to evaluate the prognostic value of OPN in patients with HCC. METHODS: Eligible studies were systematically searched by PubMed, EMBASE, and Google scholar. A meta-analysis of 12 studies included 2117 cases was performed to estimate the association between OPN level and overall survival (OS), disease-free survival (DFS) in HCC patients. Subgroup analyses were also performed in the meta-analysis. RESULTS: The pooled data of studies showed that high OPN level was significantly associated with poor OS (hazard ratios [HR] 1.84; 95% confidence intervals [CI] 1.54–2.20; P = .000) and DFS (HR 1.67; 95% CI 1.40–1.98; P = .000) in HCC. Furthermore, in subgroup analysis, high tissue based OPN by immunohistochemistry detection and serum-based OPN by enzyme-linked immunosorbent assay (ELISA) detection were both significantly associated with OS (tissue: HR 1.88; 95% CI 1.53–2.31; P < .0001; serum: HR 2.38; 95% CI 1.58–3.59; P < .0001). Simultaneously, we also found that OPN expression was positively associated with stage (odds ratios [OR] 5.68; 95% CI 3.443–7.758), tumor size (Size≤5 cm vs >5 cm; OR 2.001; 95% CI1.036–3.867). CONCLUSION: The current evidence indicates that OPN could serve as a prognostic biomarker and a potential therapeutic target for HCC. |
format | Online Article Text |
id | pubmed-6221565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-62215652018-12-04 Prognostic value of osteopontin in patients with hepatocellular carcinoma: A systematic review and meta-analysis Sun, Tingting Li, Peng Sun, Diwen Bu, Qingao Li, Guoqiang Medicine (Baltimore) Research Article PURPOSE: The prognostic value of tissue and serum osteopontin (OPN) in hepatocellular carcinoma (HCC) remain controversial. The aim of present meta-analysis was to evaluate the prognostic value of OPN in patients with HCC. METHODS: Eligible studies were systematically searched by PubMed, EMBASE, and Google scholar. A meta-analysis of 12 studies included 2117 cases was performed to estimate the association between OPN level and overall survival (OS), disease-free survival (DFS) in HCC patients. Subgroup analyses were also performed in the meta-analysis. RESULTS: The pooled data of studies showed that high OPN level was significantly associated with poor OS (hazard ratios [HR] 1.84; 95% confidence intervals [CI] 1.54–2.20; P = .000) and DFS (HR 1.67; 95% CI 1.40–1.98; P = .000) in HCC. Furthermore, in subgroup analysis, high tissue based OPN by immunohistochemistry detection and serum-based OPN by enzyme-linked immunosorbent assay (ELISA) detection were both significantly associated with OS (tissue: HR 1.88; 95% CI 1.53–2.31; P < .0001; serum: HR 2.38; 95% CI 1.58–3.59; P < .0001). Simultaneously, we also found that OPN expression was positively associated with stage (odds ratios [OR] 5.68; 95% CI 3.443–7.758), tumor size (Size≤5 cm vs >5 cm; OR 2.001; 95% CI1.036–3.867). CONCLUSION: The current evidence indicates that OPN could serve as a prognostic biomarker and a potential therapeutic target for HCC. Wolters Kluwer Health 2018-10-26 /pmc/articles/PMC6221565/ /pubmed/30412113 http://dx.doi.org/10.1097/MD.0000000000012954 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Sun, Tingting Li, Peng Sun, Diwen Bu, Qingao Li, Guoqiang Prognostic value of osteopontin in patients with hepatocellular carcinoma: A systematic review and meta-analysis |
title | Prognostic value of osteopontin in patients with hepatocellular carcinoma: A systematic review and meta-analysis |
title_full | Prognostic value of osteopontin in patients with hepatocellular carcinoma: A systematic review and meta-analysis |
title_fullStr | Prognostic value of osteopontin in patients with hepatocellular carcinoma: A systematic review and meta-analysis |
title_full_unstemmed | Prognostic value of osteopontin in patients with hepatocellular carcinoma: A systematic review and meta-analysis |
title_short | Prognostic value of osteopontin in patients with hepatocellular carcinoma: A systematic review and meta-analysis |
title_sort | prognostic value of osteopontin in patients with hepatocellular carcinoma: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221565/ https://www.ncbi.nlm.nih.gov/pubmed/30412113 http://dx.doi.org/10.1097/MD.0000000000012954 |
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